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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • PGC1 alpha/beta Antibodies

          Invitrogen

          PGC1 alpha/beta Recombinant Rabbit Monoclonal Antibody (5K0F4)

          查看其他2个PGC1 alpha/beta抗体

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          Cite PGC1 alpha/beta Recombinant Rabbit Monoclonal Antibody (5K0F4)

          • 抗体检测数据 (1)
          PGC1 alpha/beta Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          PGC1 alpha/beta Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          图: 1 / 1

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          PGC1 alpha/beta Antibody (MA5-37948) in WB

          Western blot analysis of PGC1 alpha/beta in extracts of various cell lines. Samples were incubated with PGC1 alpha/beta Monoclonal antibody (Product # MA5-37948) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s. {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
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          PGC1 alpha/beta Antibody in Western Blot (WB)
          PGC1 alpha/beta Recombinant Rabbit Monoclonal Antibody (5K0F4)

          产品信息

          MA5-37948

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:1,000-1:6,000
          -

          酶联免疫吸附实验 (ELISA)

          1 µg/mL
          -
          产品规格

          种属反应

          Human, Mouse, Rat

          宿主/亚型

          Rabbit / IgG

          Expression System

          HEK293 cells

          分类

          Recombinant Monoclonal

          类型

          Antibody

          克隆号

          5K0F4

          抗原

          A synthetic peptide corresponding to a sequence within amino acids 699-798 of human PGC1alpha/beta (NP_0373931)
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          1.5 mg/mL

          纯化类型

          Affinity chromatography

          保存液

          PBS, pH 7.3, with 0.05% BSA, 50% glycerol

          内含物

          0.02% sodium azide

          保存条件

          -20°C, Avoid Freeze/Thaw Cycles

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2897868

          产品详细信息

          Positive Samples: Mouse liver, Rat heart

          Immunogen sequence: VFGEIEECTV NLRDDGDSYG FITYRYTCDA FAALENGYTL RRSNETDFEL YFCGRKQFFK SNYADLDSNS DDFDPASTKS KYDSLDFDSL LKEAQRSLRR

          靶标信息

          PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. Ectopic expression of this protein has been shown to lead to increased mitochondrial number and basal oxygen consumption.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: ERR ligand 1; L-PGC-1alpha; Ligand effect modulator 6; ligand effect modulator-6; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferative activated receptor, gamma, coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; peroxisome proliferator-activated receptor gamma coactivator 1 beta; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a; peroxisome proliferator-activated receptor gamma coactivator-1 alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; pgc-1 alpha; pgc-1 beta; PGC-1-alpha; PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC-1alpha; Pgc-1alphaa; PGC-1beta; PGC-1beta/ERRL1; PPAR gamma coactivator variant form; PPAR Gamma Coactivator-1; PPAR gamma coactivator-1beta protein; PPAR-gamma coactivator 1-alpha; PPAR-gamma coactivator 1-beta; PPARgamma coactivator 1 beta; PPARgamma coactivator 1alpha; PPARGC-1-alpha; PPARGC-1-beta

          查看更多 收起

          基因别名: 4631412G21Rik; A830037N07Rik; ENSMUSG00000079510; ERRL1; Gm11133; LEM6; PERC; PGC-1; PGC-1(alpha); PGC-1(beta); PGC-1alpha; PGC-1v; PGC1; PGC1A; PGC1B; PGC1beta; Pgco1; PPARGC1; PPARGC1A; PPARGC1B

          查看更多 收起

          UniProt ID: (Human) Q9UBK2, (Human) Q86YN6, (Mouse) O70343, (Rat) Q9QYK2, (Rat) Q811R2, (Mouse) Q8VHJ7

          查看更多 收起

          Entrez Gene ID: (Human) 10891, (Human) 133522, (Mouse) 19017, (Rat) 83516, (Rat) 291567, (Mouse) 170826

          查看更多 收起

          功能
          nucleotide binding RNA polymerase II transcription cofactor activity DNA binding transcription coactivator activity RNA binding protein binding transcription factor binding ligand-dependent nuclear receptor binding estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity chromatin DNA binding ubiquitin protein ligase binding peroxisome proliferator activated receptor binding alpha-tubulin binding sequence-specific DNA binding androgen receptor binding promoter-specific chromatin binding receptor activator activity AF-2 domain binding nucleic acid binding chromatin binding molecular_function transcription cofactor
          参与通路
          response to reactive oxygen species mitophagy temperature homeostasis cellular glucose homeostasis negative regulation of protein phosphorylation response to dietary excess response to ischemia galactose metabolic process gluconeogenesis regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter mRNA processing protein complex assembly mitochondrion organization positive regulation of transcription from RNA polymerase II promoter by pheromones aging digestion circadian rhythm androgen metabolic process RNA splicing response to cold positive regulation of mitochondrion organization skeletal muscle atrophy response to muscle activity response to electrical stimulus involved in regulation of muscle adaptation negative regulation of smooth muscle cell migration fatty acid oxidation cerebellum development respiratory electron transport chain androgen receptor signaling pathway forebrain development circadian regulation of gene expression cellular response to oxidative stress positive regulation of histone acetylation cellular response to potassium ion response to statin response to drug response to starvation regulation of circadian rhythm response to leucine negative regulation of neuron apoptotic process cellular respiration positive regulation of gluconeogenesis negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation protein stabilization brown fat cell differentiation positive regulation of sequence-specific DNA binding transcription factor activity flavone metabolic process adipose tissue development cellular response to lipopolysaccharide cellular response to nitrite cellular response to caffeine cellular response to fructose stimulus cellular response to glucose stimulus cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to follicle-stimulating hormone stimulus cellular response to estradiol stimulus cellular response to hypoxia cellular response to transforming growth factor beta stimulus response to epinephrine response to norepinephrine negative regulation of mitochondrial fission cellular response to thyroid hormone stimulus negative regulation of neuron death response to metformin positive regulation of cellular respiration positive regulation of mitochondrial DNA metabolic process positive regulation of muscle tissue development positive regulation of glomerular visceral epithelial cell apoptotic process cellular response to ionomycin cellular response to resveratrol response to methionine adaptive thermogenesis positive regulation of progesterone biosynthetic process negative regulation of receptor activity regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of energy homeostasis positive regulation of ATP biosynthetic process ossification transcription from mitochondrial promoter actin filament organization positive regulation of alkaline phosphatase activity intracellular estrogen receptor signaling pathway cellular response to reactive oxygen species positive regulation of phosphorylation positive regulation of osteoclast differentiation positive regulation of bone resorption negative regulation of transcription, DNA-templated response to glucocorticoid response to cAMP bone trabecula formation positive regulation of receptor activity transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter positive regulation of cellular metabolic process rhythmic process response to hypoxia response to organic cyclic compound response to activity response to nutrient levels cellular response to fatty acid
          It has to be done as per old AB suggested Products section.
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