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Invitrogen
PGC1 alpha/beta Recombinant Rabbit Monoclonal Antibody (5K0F4)
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PGC1 alpha/beta Antibody (MA5-37948) in WB
Western blot analysis of PGC1 alpha/beta in extracts of various cell lines. Samples were incubated with PGC1 alpha/beta Monoclonal antibody (Product # MA5-37948) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-37948
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5K0F4
抗原
Synthetic peptide
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
2 mg/mL
规格
200 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: Mouse liver, Rat heart
Immunogen sequence: VFGEIEECTV NLRDDGDSYG FITYRYTCDA FAALENGYTL RRSNETDFEL YFCGRKQFFK SNYADLDSNS DDFDPASTKS KYDSLDFDSL LKEAQRSLRR
靶标信息
PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. Ectopic expression of this protein has been shown to lead to increased mitochondrial number and basal oxygen consumption.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ERR ligand 1; L-PGC-1alpha; ligand effect modulator-6; PERC; PERC-s; lacks one estrogen receptor interaction domain; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferative activated receptor, gamma, coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PGC-1; pgc-1 alpha; pgc-1 beta; PGC-1-alpha; PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC-1alpha; PGC1beta-1a; PGC1beta-1b; PGC1beta-2a; PGC1beta-2b; PPAR gamma coactivator 1alpha variant form-1; PPAR gamma coactivator variant form; PPAR gamma coactivator-1beta protein; PPAR-gamma coactivator 1-alpha; PPAR-gamma coactivator 1-beta; PPARAGCIalpha; PPARAGCIbeta; PPARgamma coactivator 1 beta; PPARgamma coactivator 1alpha; PPARGC-1-alpha; PPARGC-1-beta; Ppargc1a-vf1; transcriptional coactivator; transcriptional coactivator; PGC-1; unnamed protein product
基因别名: 4631412G21Rik; A830037N07Rik; ERRL1; Gm11133; LEM6; LRPGC1; PERC; PGC-1; PGC-1(alpha); PGC-1(beta); PGC-1alpha; PGC-1beta; PGC-1beta/ERRL1; PGC-1v; PGC1; PGC1A; PGC1B; PGC1beta; Pgco1; PGCvf; PGCvf-1; PGCvf1; PPARGC-1-alpha; PPARGC-1-beta; PPARGC1
UniProt ID: (Human) Q9UBK2, (Human) Q86YN6, (Mouse) O70343, (Rat) Q9QYK2, (Mouse) Q8VHJ7, (Rat) Q811R2
Entrez Gene ID: (Human) 10891, (Human) 133522, (Mouse) 19017, (Rat) 83516, (Mouse) 170826, (Rat) 291567
nucleic acid binding
DNA binding
transcription cofactor activity
transcription coactivator activity
RNA binding
protein binding
ligand-dependent nuclear receptor binding
chromatin DNA binding
ubiquitin protein ligase binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
lncRNA binding
DNA-binding transcription factor binding
estrogen receptor binding
AF-2 domain binding
chromatin binding
peroxisome proliferator activated receptor binding
alpha-tubulin binding
promoter-specific chromatin binding
negative regulation of protein phosphorylation
response to dietary excess
gluconeogenesis
regulation of transcription, DNA-templated
mitochondrion organization
positive regulation of gene expression
response to activity
response to muscle activity
negative regulation of smooth muscle cell migration
respiratory electron transport chain
developmental process
circadian regulation of gene expression
cellular response to oxidative stress
regulation of circadian rhythm
negative regulation of neuron apoptotic process
positive regulation of gluconeogenesis
negative regulation of glycolytic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fatty acid oxidation
negative regulation of smooth muscle cell proliferation
multicellular organismal homeostasis
adipose tissue development
cellular response to follicle-stimulating hormone stimulus
cellular response to transforming growth factor beta stimulus
negative regulation of mitochondrial fission
energy homeostasis
cellular response to thyroid hormone stimulus
positive regulation of cold-induced thermogenesis
positive regulation of glomerular visceral epithelial cell apoptotic process
positive regulation of vascular smooth muscle cell proliferation
positive regulation of progesterone biosynthetic process
negative regulation of receptor activity
regulation of N-methyl-D-aspartate selective glutamate receptor activity
intracellular estrogen receptor signaling pathway
positive regulation of osteoclast differentiation
response to nutrient
response to glucocorticoid
response to cAMP
temperature homeostasis
cellular glucose homeostasis
transcription initiation from RNA polymerase II promoter
mRNA processing
digestion
RNA splicing
fatty acid oxidation
response to starvation
cellular respiration
protein stabilization
brown fat cell differentiation
protein-containing complex assembly
response to reactive oxygen species
mitophagy
response to hypoxia
response to ischemia
galactose metabolic process
response to xenobiotic stimulus
response to fructose
skeletal muscle atrophy
response to electrical stimulus involved in regulation of muscle adaptation
cerebellum development
forebrain development
response to nutrient levels
cellular response to potassium ion
response to leucine
response to morphine
response to electrical stimulus
cellular response to lipopolysaccharide
cellular response to nitrite
cellular response to caffeine
cellular response to fructose stimulus
cellular response to glucose stimulus
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to estradiol stimulus
cellular response to fatty acid
cellular response to hypoxia
response to epinephrine
response to norepinephrine
response to thyroid hormone
response to dehydroepiandrosterone
cellular response to ionomycin
cellular response to resveratrol
response to methionine
adaptive thermogenesis
response to hypobaric hypoxia
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