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The transcription factor peroxisome proliferator-activated receptor -gamma (PPARg) plays essential roles in adipogenesis by regulating adipocyte-specific genes through association of various co-factors. One such co-factor, PGCC1 (also known as FAM120B), is widely expressed in adult tissues and throughout embryonic development. Overexpression of this protein in OP9 pre-adipocytes promoted their differentiation into adipocytes, and knockdown of PGCC1 expression through RNA interference blocked this process. PGCC1 is homologous to C9orf10 (also known as FAM120A) and has been mapped to chromosome Xp11.22. At least two isoforms of PGCC1 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Constitutive coactivator of peroxisome proliferator-activated receptor gamma; Constitutive coactivator of PPAR-gamma; constitutive coactivator of PPARG; f120b; family with sequence similarity 120B; PGCC1; PPARG constitutive coactivator 1; PPARgamma constitutive coactivator 1; Protein FAM120B
基因别名: 4932442K08Rik; AW049283; AW413338; CCPG; dJ894D12.1; FAM120B; KIAA1838; mKIAA1838; PGCC1; RGD1310304
UniProt ID: (Human) Q96EK7, (Mouse) Q6RI63
Entrez Gene ID: (Human) 84498, (Mouse) 67544, (Rat) 308218