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Invitrogen
PGPEP1 Polyclonal Antibody
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PGPEP1 Antibody (PA5-47827) in WB
Western blot analysis of PGPEP1 in LNCaP human prostate cancer cell line, JAR human choriocarcinoma cell line, NTera‚2 human testicular embryonic carcinoma cell line, Neuro‚2A mouse neuroblastoma cell line, and human brain (cortex) tissue. Samples were incubated in PGPEP1 polyclonal antibody (Product # PA5-47827) using a dilution of 1 µg/mL followed by a HRP-conjugated Anti-Sheep IgG secondary antibody. A specific band was detected for PGPEP‚1 at approximately 23 kDa (as indicated). This experiment was conducted under reducing conditions.
产品信息
PA5-47827
产品规格
种属反应
Human,
Mouse
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant human PGPEP-1 Met1-His209
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
靶标信息
Pyroglutamyl-peptidase I (PGPEP1) is a gene located on chromosome 19q13.33, encoding an enzyme involved in the removal of pyroglutamyl residues from the N-terminus of peptides and proteins. This enzymatic activity is fundamental in protein processing and metabolism, ensuring proper protein maturation and degradation. PGPEP1 is expressed in multiple tissues, including the liver and kidney, and plays a role in the regulation of biological processes by modulating the activity and stability of pyroglutamyl-containing bioactive peptides. The enzyme's function is crucial for maintaining cellular homeostasis and can influence physiological pathways such as hormone regulation and immune responses. Dysregulation or mutations in PGPEP1 may impact peptide function and have potential implications for various diseases, although the specific clinical significance is still being researched. Insights into PGPEP1's function are contributing to the understanding of protease-related disorders and therapeutic strategies targeting peptide metabolism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5-oxoprolyl-peptidase; PAP-I; pGlu-peptidase I; PGP-I; putative pyroglutamyl-peptidase I; Pyroglutamyl aminopeptidase I; Pyroglutamyl-peptidase 1; Pyroglutamyl-peptidase I; Pyrrolidone-carboxylate peptidase
基因别名: 2810003H13Rik; Gm19458; PAP-I; Pcp; PGI; PGP; PGP-I; PGPEP1; PGPI
UniProt ID: (Human) Q9NXJ5, (Mouse) Q9ESW8
Entrez Gene ID: (Human) 54858, (Mouse) 66522
