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Invitrogen
PHEX Polyclonal Antibody
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PHEX Antibody (PA5-143870) in IHC (P)
Immunohistochemistry analysis of PHEX in paraffin-embedded section of human ovarian cancer tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. Samples were incubated with PHEX Polyclonal antibody (Product # PA5-143870) using a dilution of 1 μg/mL overnight at 4°C. Biotinylated goat anti-rabbit IgG was ... View More
产品信息
PA5-143870
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human PHEX recombinant protein (Position: E145-N718).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: rat ovary tissue, rat kidney tissue, mouse ovary tissue, mouse kidney tissue, human HEK293 whole cell, monkey kidney tissue, rat NRK whole cell, monkey COS-7 whole cell. IHC: human lung cancer tissue, human ovarian cancer tissue. Flow: U87 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity. Cleaves ASARM peptides between Ser and Glu or Asp residues. Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide. Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides. Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HYP; Metalloendopeptidase homolog PEX; Metalloendopeptidase homolog PEX (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein); phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets); Phosphate regulating neutral endopeptidase; Phosphate regulating neutral endopeptidase on the X chromosome (X-linked hypophosphatemia XLH); phosphate-regulating neutral endopeptidase; Phosphate-regulating neutral endopeptidase PHEX; Vitamin D-resistant hypophosphatemic rickets protein; X-linked hypophosphatemia protein; X-linked phosphate regulating endopeptidase
基因别名: Gy; HPDR; HPDR1; HYP; HYP1; LXHR; PEX; PHEX; XLH
UniProt ID: (Human) P78562, (Mouse) P70669
Entrez Gene ID: (Human) 5251, (Mouse) 18675, (Rat) 25512
