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Invitrogen
PHOX2B Polyclonal Antibody
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产品信息
PA5150788
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.05 mg/mL
规格
5 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Highest antigen sequence identity to the following orthologs: Mouse- 100%, Rat- 100%.
Sequence of this protein is as follows: MEYSYLNSSA YESCMAGMDT SSLASAYADF SSCSQASGFQ YNPIRTTFGA TSGCPSLTPG SCSLGTLRDH QS
靶标信息
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: NBPhox; neuroblastoma paired-type homeobox protein; Neuroblastoma Phox; paired like homeobox2B; paired mesoderm homeobox 2b; Paired mesoderm homeobox protein 2B; Paired-like homeobox 2B; PHOX2B homeodomain protein
基因别名: CCHS; NBLST2; NBPhox; PHOX2B; PMX2B
UniProt ID: (Human) Q99453
Entrez Gene ID: (Human) 8929
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
sequence-specific double-stranded DNA binding
neuron migration
regulation of respiratory gaseous exchange by neurological system process
noradrenergic neuron differentiation
noradrenergic neuron development
brainstem development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell proliferation
glial cell differentiation
regulation of gene expression
positive regulation of G2/M transition of mitotic cell cycle
response to activity
cell differentiation in hindbrain
medullary reticular formation development
hindbrain tangential cell migration
neuron differentiation
skeletal muscle cell differentiation
type B pancreatic cell proliferation
negative regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
cell development
autonomic nervous system development
enteric nervous system development
sympathetic nervous system development
parasympathetic nervous system development
neuron development
inner ear development
efferent axon development in a lateral line nerve
membrane depolarization
respiratory system development
retrotrapezoid nucleus neuron differentiation
sympathetic ganglion development
cellular response to carbon dioxide
dopaminergic neuron differentiation
cellular response to BMP stimulus
motor neuron migration
positive regulation of cold-induced thermogenesis
neural crest cell migration involved in autonomic nervous system development
negative regulation of type B pancreatic cell proliferation
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