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PI3K p85 alpha Monoclonal Antibody (A3-D0)

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PI3K p85 alpha Monoclonal Antibody (A3-D0)

产品信息

MA5-32917

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:2,000
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免疫细胞化学 (ICC/IF)

1:50-1:200
-
产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

A3-D0

抗原

Recombinant protein within Human PI3-kinase p85 subunit alpha aa 19-219.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4, with 40% Glycerol, 0.2% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2802552

靶标信息

Phosphatidylinositol 3-kinase (PIK3) is a signaling protein that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Signaling is initiated when upstream tyrosine kinase receptors or G protein coupled receptors are bound by their ligands. It binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. During insulin stimulation, it also binds to IRS-1. Mutations in the gene can result in Agammaglobulinemia 7, SHORT syndrome, or Immunodeficiency 36.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: growth factor receptor bound 1; p55-GAMMA; p55PIK; p85-alpha; GRB1; phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit gamma; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase-associated p-85 alpha; phosphoinositide-3-kinase regulatory subunit alpha; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); PI3 kinase-associated p85; PI3-kinase p85-subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; PI3K regulatory subunit gamma; PI3K-p46; polypeptide 1 p85 alpha; ptdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase regulatory subunit p85-al; RP4-533D7.2; unnamed protein product

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基因别名: AGM7; GRB1; IMD36; p85; p85-ALPHA; p85alpha; PIK3R1

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UniProt ID: (Human) P27986

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Entrez Gene ID: (Human) 5295

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功能
phosphotyrosine binding transmembrane receptor protein tyrosine kinase adaptor activity GTPase activator activity insulin receptor binding insulin-like growth factor receptor binding neurotrophin TRKA receptor binding protein binding kinase regulator activity kinase activator activity protein phosphatase binding phosphatidylinositol 3-kinase regulator activity phosphatidylinositol 3-kinase regulatory subunit binding ErbB-3 class receptor binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding 1-phosphatidylinositol-3-kinase regulator activity protein heterodimerization activity phosphatidylinositol kinase activity enzyme-substrate adaptor activity phosphatidylinositol 3-kinase activator activity
参与通路
cellular glucose homeostasis negative regulation of cell-matrix adhesion positive regulation of leukocyte migration transcription from RNA polymerase II promoter protein import into nucleus immune response negative regulation of cell adhesion signal transduction insulin receptor signaling pathway extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of lamellipodium assembly protein transport cytokine-mediated signaling pathway B cell differentiation T cell differentiation osteoclast differentiation positive regulation of tumor necrosis factor production cellular response to insulin stimulus positive regulation of RNA splicing regulation of toll-like receptor 4 signaling pathway substrate adhesion-dependent cell spreading cellular response to UV response to endoplasmic reticulum stress interleukin-18-mediated signaling pathway natural killer cell mediated cytotoxicity positive regulation of protein import into nucleus negative regulation of apoptotic process protein kinase B signaling negative regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import phosphatidylinositol phosphorylation insulin-like growth factor receptor signaling pathway positive regulation of smooth muscle cell proliferation protein stabilization positive regulation of filopodium assembly regulation of stress fiber assembly negative regulation of stress fiber assembly growth hormone receptor signaling pathway T follicular helper cell differentiation myeloid leukocyte migration positive regulation of focal adhesion disassembly positive regulation of endoplasmic reticulum unfolded protein response regulation of protein localization to plasma membrane positive regulation of protein localization to plasma membrane
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