Abnova

PIAS1/2/3 Recombinant Rabbit Monoclonal Antibody

Name: PIAS1\/2\/3 Recombinant Rabbit Monoclonal Antibody
Brand: Abnova
SKU: RAB06469

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

产品信息

RAB06469

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化（石蜡） (IHC (P))

1:50-1:100

免疫细胞化学 (ICC/IF)

1:50-1:200

流式细胞分析 (Flow)

1:50-1:100

免疫沉淀 (IP)

1:20

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

CHO cells

分类

Recombinant Monoclonal

类型

Antibody

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_3709080

靶标信息

PIAS1, PIAS2, and PIAS3 are members of the Protein Inhibitor of Activated STAT (PIAS) family, which are integral to cellular processes such as SUMOylation, transcriptional regulation, and signal transduction. PIAS1 is noted for its role as a chromatin-bound androgen receptor (AR) coregulator, influencing AR-mediated target gene regulation in prostate cancer cells. It interacts with and modifies AR via SUMO3, which affects cell proliferation. PIAS2, another member, has been implicated in the inhibition of the JAK-STAT signaling pathway, notably suppressing STAT4-dependent gene induction linked to IL-12. Furthermore, PIAS2 has been shown to repress IFN-B production, highlighting its regulatory role in immune response mechanisms. PIAS3 is recognized as a SUMO E3 ligase that binds activated STAT3 and inhibits its DNA binding ability, subsequently hindering STAT3-mediated gene activation. Elevated expression of PIAS3 in prostate cancer samples has been associated with apoptosis induction. Together, the PIAS family genes are increasingly acknowledged in cancer biology due to their contributions to growth regulation and metastasis, while also representing potential therapeutic targets in cancer treatment strategies.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Androgen receptor-interacting protein 3; AR interacting protein; ARIP3; DAB2-interacting protein; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; DIP; E3 SUMO-protein ligase PIAS1; E3 SUMO-protein ligase PIAS2; E3 SUMO-protein ligase PIAS3; E3 SUMO-protein transferase PIAS1; E3 SUMO-protein transferase PIAS2; E3 SUMO-protein transferase PIAS3; GBP; Gu-binding protein; KChAP; Miz1; Msx-interacting zinc finger protein; Msx-interacting-zinc finger; Msx-interacting-zinc finger protein; PIAS-NY protein; PIASxalpha6; potassium channel regulatory protein KChAP; Potassium channel-associated protein; Protein inhibitor of activated STAT protein 1; Protein inhibitor of activated STAT protein 3; Protein inhibitor of activated STAT x; protein inhibitor of activated STAT, 3; protein inhibitor of activated STAT-1; Protein inhibitor of activated STAT2; RING-type E3 ubiquitin transferase PIAS1; RING-type E3 ubiquitin transferase PIAS2; RNA helicase II-binding protein; zinc finger, MIZ-type containing 3; zinc finger, MIZ-type containing 4; zinc finger, MIZ-type containing 5

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基因别名: 2900068C24Rik; 6330408K17Rik; AI462206; ARIP3; AU018068; DDXBP1; Dib; DIP; GBP; GU/RH-II; MIZ; MIZ1; PIAS1; PIAS2; PIAS3; Pias3l; PIASX; PIASX-ALPHA; PIASX-BETA; PIASxalpha; PIASxb; PIASxbeta; SIZ2; ZMIZ3; ZMIZ4; ZMIZ5