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Abnova
PIAS1/2 Recombinant Rabbit Monoclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
RAB04414
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
纯化类型
Affinity chromatography
保存液
50mM tris glycine, pH 7.4, with 40% glycerol, 0.05% BSA, 150mM NaCl
内含物
0.01% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: androgen receptor-interacting protein 3; AR interacting protein; DAB2-interacting protein; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; E3 SUMO-protein transferase PIAS1; E3 SUMO-protein transferase PIAS2; gu-binding protein; msx-interacting zinc finger protein; nuclear protein that binds to nucleolar RNA helicase Gu protein and to p53; PIAS1/GBP; PIG23; protein inhibitor of activated STAT protein 1; protein inhibitor of activated STAT X; RNA helicase II-binding protein; unnamed protein product; zinc finger, MIZ-type containing 3; zinc finger, MIZ-type containing 4
基因别名: ARIP3; DDXBP1; DIP; GBP; GU/RH-II; MIZ1; PIASX; SIZ2; ZMIZ3; ZMIZ4
UniProt ID: (Human) O75925, (Human) O75928
Entrez Gene ID: (Human) 8554, (Human) 9063
transcription regulatory region sequence-specific DNA binding
transcription cofactor activity
transcription corepressor activity
protein binding
zinc ion binding
SUMO transferase activity
enzyme binding
protein domain specific binding
ubiquitin protein ligase binding
SUMO ligase activity
DNA-binding transcription factor binding
transcription regulator inhibitor activity
DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
regulation of transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
protein sumoylation
endoplasmic reticulum unfolded protein response
negative regulation of transcription, DNA-templated
negative regulation of JAK-STAT cascade
SMAD protein signal transduction
negative regulation of androgen receptor signaling pathway
G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
JAK-STAT cascade
spermatogenesis
visual learning
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein sumoylation
regulation of cell proliferation
negative regulation of apoptotic process
fat cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell differentiation
positive regulation of transcription initiation from RNA polymerase II promoter
protein-DNA complex assembly
positive regulation of protein localization to cell periphery
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