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Invitrogen
PIAS1/PIAS2 Recombinant Rabbit Monoclonal Antibody (10G6)
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图: 1 / 18
PIAS1/PIAS2 Antibody (MA573419) in ICC/IF
Immunocytochemistry analysis of PIAS1/PIAS2 in HepG2 cells. Permeabilized with Trinton X-100 at room temp for 20 min. Samples were incubated with PIAS1/PIAS2 Recombinant Monoclonal (Product # MA573419 using a dilution at 1:100, for 90 min at 37°C. Followed by conjugated Goat Anti-Rabbit IgG antibody (green) at 37°C for 90 min, DAPI was used to stain the cell nuclei. PBS instead of the primary antibody was u... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA573419
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
10G6
抗原
KLH conjugated synthetic peptide derived from human PIAS1.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
20 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Androgen receptor-interacting protein 3; ARIP3; DAB2-interacting protein; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; DIP; E3 SUMO-protein ligase PIAS1; E3 SUMO-protein ligase PIAS2; E3 SUMO-protein transferase PIAS1; E3 SUMO-protein transferase PIAS2; GBP; Gu-binding protein; Miz1; Msx-interacting zinc finger protein; Msx-interacting-zinc finger; Msx-interacting-zinc finger protein; PIAS-NY protein; PIASxalpha6; Protein inhibitor of activated STAT protein 1; Protein inhibitor of activated STAT x; Protein inhibitor of activated STAT2; RING-type E3 ubiquitin transferase PIAS1; RING-type E3 ubiquitin transferase PIAS2; RNA helicase II-binding protein
基因别名: 2900068C24Rik; 6330408K17Rik; AI462206; ARIP3; AU018068; DDXBP1; Dib; GBP; Miz1; PIAS1; PIAS2; PIASX; PIASxalpha; PIASxb; PIASxbeta; SIZ2
UniProt ID: (Mouse) O88907, (Rat) Q6AZ28, (Mouse) Q8C5D8
Entrez Gene ID: (Mouse) 56469, (Rat) 300772, (Rat) 83422, (Mouse) 17344
DNA binding
transcription corepressor activity
protein binding
protein C-terminus binding
transcription factor binding
zinc ion binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
SUMO transferase activity
enzyme binding
protein domain specific binding
ubiquitin protein ligase binding
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
SUMO ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
estrogen receptor binding
glucocorticoid receptor binding
androgen receptor binding
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatogenesis
metabolic process
response to organic substance
protein sumoylation
androgen receptor signaling pathway
response to testosterone
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of dendrite morphogenesis
regulation of androgen receptor signaling pathway
negative regulation of androgen receptor signaling pathway
G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
JAK-STAT cascade
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein sumoylation
regulation of cell proliferation
negative regulation of apoptotic process
fat cell differentiation
positive regulation of smooth muscle cell differentiation
protein-DNA complex assembly
negative regulation of nucleic acid-templated transcription
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