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Invitrogen
PIK3CA Polyclonal Antibody
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Product Details
PA5-85091
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human PI3 kinase p110 alpha. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (98%), Rat (99%), Chicken (95%), Rhesus Monkey (100%), Bovine (100%).
Positive Control: H1299, HCT116, C2C12, C2C12+AEA10mM, mouse brain.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2.7.1.153; EC:2.7.11.1; GRB1; MGC142161; MGC142163; mutant phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3-kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3K alpha; PI3K-alpha; PI3Kalpha; pi3kca; PIK3R1; pk3ca; ptdIns-3-kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; Serine/threonine protein kinase PIK3CA; unnamed protein product
Gene Aliases: 6330412C24Rik; caPI3K; CCM4; CLAPO; CLOVE; CWS5; HMH; MCAP; MCM; MCMTC; p110; p110-alpha; p110alpha; PI3K; PI3K-alpha; PIK3CA
UniProt ID: (Human) P42336, (Mouse) P42337
Entrez Gene ID: (Human) 5290, (Mouse) 18706
nucleotide binding
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
1-phosphatidylinositol-3-kinase activity
transferase activity
protein kinase activator activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
insulin receptor substrate binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
kinase
angiogenesis
liver development
vasculature development
glucose metabolic process
lipid metabolic process
phagocytosis
epidermal growth factor receptor signaling pathway
insulin receptor signaling pathway
regulation of gene expression
positive regulation of lamellipodium assembly
negative regulation of gene expression
response to activity
response to muscle inactivity
negative regulation of macroautophagy
cell migration
actin cytoskeleton organization
platelet activation
negative regulation of actin filament depolymerization
positive regulation of TOR signaling
cellular response to insulin stimulus
response to muscle stretch
phosphatidylinositol-3-phosphate biosynthetic process
vascular endothelial growth factor signaling pathway
regulation of multicellular organism growth
response to leucine
anoikis
regulation of cellular respiration
protein kinase B signaling
negative regulation of neuron apoptotic process
endothelial cell migration
phosphatidylinositol phosphorylation
insulin-like growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of smooth muscle cell proliferation
T cell receptor signaling pathway
positive regulation of protein kinase B signaling
relaxation of cardiac muscle
cardiac muscle contraction
adipose tissue development
cellular response to glucose stimulus
cellular response to hydrostatic pressure
response to dexamethasone
cardiac muscle cell contraction
energy homeostasis
regulation of actin filament organization
autosome genomic imprinting
response to butyrate
positive regulation of protein localization to membrane
negative regulation of fibroblast apoptotic process
negative regulation of anoikis
adaptive immune response
protein phosphorylation
inflammatory response
phosphatidylinositol 3-kinase signaling
phosphorylation
positive regulation of peptidyl-serine phosphorylation
hypomethylation of CpG island
innate immune response
positive regulation of protein kinase activity
cell chemotaxis
mitophagy in response to mitochondrial depolarization
regulation of genetic imprinting
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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