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PIK3CA Monoclonal Antibody (3G3)

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PIK3CA Monoclonal Antibody (3G3)

产品信息

H00005290-M01

应用
建议稀释比
已发表文章

酶联免疫吸附实验 (ELISA)

10 µg/mL
-

Proximity Ligation Assay (PLA) (PLA)

1:50-1:2,000
-
产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

3G3

抗原

PIK3CA (NP_006209, 959 a.a. approximately 1068 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.44 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Immunogen sequence: DFLIVISKGA QECTKTREFE RFQEMCYKAY LAIRQHANLF INLFSMMLGS GMPELQSFDD IAYIRKTLAL DKTEQEALEY FMKQMNDAHH GGWTTKMDWI FHTIKQHALN

靶标信息

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: 2.7.1.153; EC:2.7.11.1; GRB1; MGC142161; MGC142163; phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; phosphoinositide-3-kinase, catalytic, alpha polypeptide; PI3-kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3K alpha; pi3kca; PIK3R1; pk3ca; PtdIns-3-kinase subunit p110-alpha; Serine/threonine protein kinase PIK3CA

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基因别名: CLOVE; CWS5; MCAP; MCM; MCMTC; p110-alpha; PI3K; PI3K-alpha; PIK3CA

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UniProt ID: (Human) P42336

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Entrez Gene ID: (Human) 5290

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功能
protein serine/threonine kinase activity protein binding ATP binding kinase activity 1-phosphatidylinositol-3-kinase activity protein kinase activator activity phosphatidylinositol 3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity kinase
参与通路
angiogenesis liver development vasculature development glucose metabolic process protein phosphorylation phosphatidylinositol biosynthetic process epidermal growth factor receptor signaling pathway regulation of gene expression regulation of phosphatidylinositol 3-kinase signaling platelet activation T cell costimulation activation of protein kinase activity positive regulation of peptidyl-serine phosphorylation phosphatidylinositol-3-phosphate biosynthetic process insulin receptor signaling pathway via phosphatidylinositol 3-kinase Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis ERBB2 signaling pathway regulation of multicellular organism growth regulation of cellular respiration protein kinase B signaling negative regulation of neuron apoptotic process endothelial cell migration hypomethylation of CpG island phosphatidylinositol phosphorylation vascular endothelial growth factor receptor signaling pathway phosphatidylinositol-mediated signaling T cell receptor signaling pathway leukocyte migration cardiac muscle contraction adipose tissue development cellular response to glucose stimulus energy homeostasis mitophagy in response to mitochondrial depolarization negative regulation of fibroblast apoptotic process regulation of genetic imprinting negative regulation of anoikis
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