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Invitrogen
PIKFYVE Polyclonal Antibody
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PIKFYVE Antibody (PA5-13977) in IHC (P)
Immunohistochemistry analysis of PIKFYVE in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with PIKFYVE polyclonal antibody (Product # PA5-13977) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = ... View More
产品信息
PA5-13977
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 1531-1561 amino acids from the central region of human PIP5K3
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Size-exclusion - Dialysis, Ammonium sulfate precipitation
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
PIKFYVE belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol. The content of phosphatidylinositol 3,5-bisphosphateP2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. PIKFYVE is the PtdIns(3,5)P2-producing component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PIKFYVE activator VAC14 and the PtdIns(3,5)P2 phosphatase FIG4. In addition to its phosphoinositide 5-kinase activity, PIKFYVE also has protein kinase activity. For a review, see Shisheva.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 1-phosphatidylinositol 3-phosphate 5-kinase; 1-phosphatidylinositol-3-phosphate 5-kinase; epididymis luminal protein 37; FYVE finger-containing phosphoinositide kinase; Phosphatidylinositol 3-phosphate 5-kinase; Phosphatidylinositol 3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; PIKfyve; PIPkin-III; Serine-protein kinase PIKFYVE; type III PIP kinase; zinc finger, FYVE domain containing 29
基因别名: CFD; FAB1; HEL37; KIAA0981; PIKFYVE; PIP5K; PIP5K3; ZFYVE29
UniProt ID: (Human) Q9Y2I7
Entrez Gene ID: (Human) 200576
phosphatidylinositol biosynthetic process
receptor-mediated endocytosis
myelin assembly
protein localization to nucleus
intracellular signal transduction
phosphatidylinositol-3-phosphate biosynthetic process
retrograde transport, endosome to Golgi
phosphatidylinositol phosphorylation
phosphatidylinositol 5-phosphate metabolic process
regulation of autophagosome assembly
