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Abnova
PILRA Monoclonal Antibody (3C2)
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产品信息
H00029992-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
3C2
抗原
PILRA (AAH17812, 1 a.a. approximately 226 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: MGRPLLLPLL PLLLPPAFLQ PSGSTGSGPS YLYGVTQPKH LSASMGGSVE IPFSFYYPWE LATAPDVRIS WRRGHFHGQS FYSTRPPSIH KDYVNRLFLN WTEGQKSGFL RISNLQKQDQ SVYFCRVELD TRSSGRQQWQ SIEGTKLSIT QGQQRTKATT PAREPFQNTE EPYENIRNEG QNTDPKLNPK LHLTQSTSQP PSPQEPPERD PVLCLKGLTN GQPSQD
靶标信息
SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILR beta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILR alpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cell surface receptor FDF03; Inhibitory receptor PILR-alpha; paired immunoglobin-like type 2 receptor alpha; Paired immunoglobulin-like type 2 receptor alpha
基因别名: FDF03; PILRA
UniProt ID: (Human) Q9UKJ1
Entrez Gene ID: (Human) 29992
