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Invitrogen
PIM1 Polyclonal Antibody
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PIM1 Antibody (PA5-89681) in WB
Western blot analysis of PIM1 in extracts of various cell lines. Samples were incubated with PIM1 Polyclonal antibody (Product # PA5-89681) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-89681
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human PIM1 (NP_0012301151)
偶联物
形式
Liquid
浓度
0.7 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: H460, Mouse kidney, Rat kidney; Cellular Location: Cell membrane, Cytoplasm, Nucleus
Immunogen sequence: MPHEPHEPLT PPFSALPDPA GAPSRRQSRQ RPQLSSDSPS AFRASRSHSR NATRSHSHSH SPRHSLRHSP GSGSCGSSSG HRPCADILEV GMLLSKINSL AHLRAAPCND LHATKLAPGK EKEPLESQYQ VGPLLGSGGF GSVYSGIRVS DNLPVAIKHV EKDRISDWGE LPNGTRVPME VVLLKKVSSG FSGVIRLLDW FERPDSFVLI LERPEPVQDL FDFITERGAL QEELARSFFW QVLEAVRHCH NCGVLHRDIK DENILIDLNR GELKLIDFGS GALLKDTVYT DFDGTRVYSP PEWIRYHRYH GRS
靶标信息
The proto-oncogene PIM1 is upregulated in prostate cancer. PIM1, which belongs to the Serine/Threonine protein kinase family, is thought to play a role in signal transduction in blood cells. The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer. It may affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. PIM1 is expressed primarily in cells of the hematopoietic and germ line lineages.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: non-specific serine/threonine protein kinase; Oncogene PIM1; pim-1 kinase 44 kDa isoform; pim-1 oncogene; pim-1 oncogene (proviral integration site 1); proto-oncogene serine/threonine-protein kinase Pim-1; proviral integration site 1; Serine/threonine-protein kinase pim-1
基因别名: PIM; Pim-1; PIM1
UniProt ID: (Human) P11309, (Rat) P26794, (Mouse) P06803
Entrez Gene ID: (Human) 5292, (Rat) 24649, (Mouse) 18712
protein phosphorylation
apoptotic process
cell cycle
multicellular organism development
cell proliferation
hyaluronan metabolic process
negative regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
protein autophosphorylation
vitamin D receptor signaling pathway
regulation of mitotic cell cycle
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
