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Positive Control: Rat liver tissue lysate, mouse liver tissue lysate, human small intestine tissue lysate, 293T, A431, rat testis tissue, human liver tissue, human liver carcinoma tissue, human colon carcinoma tissue, mouse small intestine tissue, HepG2.
Subcellular Location: Cytoplasm.
PIM2 is a proto-oncogene which phosphorylates BAD, which partially inhibits its apopotopic function. PIM proteins (PIM-1, PIM-2 and PIM-3) are oncogene-encoded serine/threonine kinases. PIM-2 is highly homologous to Pim-1 with similar oncogenic functions. PIM-2 is most abundantly expressed in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon. PIM2 expression is negatively regulated by growth factor depletion. Increased levels of PIM-2 has also been observed in certain cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: pim-2 oncogene; Pim-2h; proto-oncogene Pim-2 (serine threonine kinase); serine/threonine protein kinase pim-2; Serine/threonine-protein kinase pim-2
基因别名: DXCch3; Pim-2; PIM2
UniProt ID: (Human) Q9P1W9, (Mouse) Q62070
Entrez Gene ID: (Human) 11040, (Rat) 317366, (Mouse) 18715