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Invitrogen
PIP5K1C Recombinant Rabbit Monoclonal Antibody (25GB1540)
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图: 1 / 4
PIP5K1C Antibody (MA570691) in ICC/IF
Immunocytochemistry analysis of PIP5K1C in HeLa cells. Sample was incubated with PIP5K1C monoclonal antibody (Product # MA570691) at a dilution of 1:1,000. Top panel: wild-type (WT); Bottom panel: PIP5K1C shRNA knockdown (KD). Nuclei were stained blue with DAPI and Alexa Fluor 647. Scale bar, 20 μm.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA570691
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
25GB1540
抗原
A synthesized peptide derived from human (1-668) PIP5K1C.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Dry ice (international)
靶标信息
PIP5K1C lipid kinase or phosphatidylinositol-4-phosphate 5-kinase 1 gamma phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1C is found at synapses and has been found to play roles in endocytosis and cell migration. PIP5K1C directly associates with -beta-catenin and increases -beta-catenin activity downstream of growth factor stimulation. PIP5K1C expression and kinase activity enhance -beta-catenin phosphorylation on residues that promote nuclear importation and transcriptional activity. PIP5K1C deficiency impairs neutrophil recruitment as a result of defect in adhesion. PIP5K1C regulated the adhesion through facilitation of RhoA GTPase and integrin activation by chemo attractants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: diphosphoinositide kinase; lipid kinase; phosphatidylinositol 4-phosphate 5-kinase type I gamma; phosphatidylinositol-4-phosphate 5-kinase; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma; phosphoinositide 5-kinase; PIP5K1-gamma; PIP5K1gamma; PIP5KI gamma; PIP5KI-gamma; PIP5KIgamma; PIPKIg_v4; ptdIns(4)P-5-kinase 1 gamma; ptdIns(4)P-5-kinase gamma; ptdInsPKIgamma; type I phosphatidylinositol 4-phosphate 5-kinase gamma; type I PIP kinase; unnamed protein product
基因别名: LCCS3; PIP5K-GAMMA; PIP5K1-gamma; PIP5Kgamma; Pip5kIgamma
UniProt ID: (Human) O60331, (Mouse) O70161, (Rat) Q5I6B8
Entrez Gene ID: (Human) 23396, (Mouse) 18717, (Rat) 314641
phosphatidylinositol biosynthetic process
axonogenesis
phosphatidylinositol metabolic process
phosphatidylinositol phosphorylation
platelet aggregation
regulation of postsynaptic neurotransmitter receptor internalization
regulation of synaptic vesicle endocytosis
phagocytosis
synaptic vesicle exocytosis
actin cytoskeleton organization
neutrophil chemotaxis
adherens junction assembly
synaptic vesicle endocytosis
regulation of protein kinase B signaling
membrane organization
clathrin-mediated endocytosis
cell-cell adhesion
biological_process
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
