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Invitrogen
PIR-A/PIR-B Monoclonal Antibody (404127)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-24140
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
404127
抗原
Mouse myeloma cell line NS0-derived recombinant mouse PIR-A1 Gly24-Met650
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
Paired Ig-like receptors of activating (PIR)-A and -B are expressed on B lymphocytes, macrophages, dendritic cells, platelets, granulocytes, and mast cells, but not on T cells, NK cells, and erythrocytes. These cell surface glycoproteins contain six extracellular Ig-like domains with distinct cytoplasmic and transmembrane regions. The PIR-A receptor activates through signaling molecules containing immunoreceptor tyrosine-based activation motifs. In contrast, the PIR-B receptor inhibits through proteins possessing immunoreceptor tyrosine-based inhibitory motifs. PIRs bind MHC class I to modulate immune system homeostasis and cell signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD85k; cell-surface glycoprotein p91; extracellular domain; Gp49b; immunoglobulin-like receptor; leukocyte immunoglobulin-like receptor 3; leukocyte immunoglobulin-like receptor subfamily B member 3; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; Lilrb4; paired immunoglobulin-like receptor; unnamed protein product
基因别名: 6M21; Gm15922; Gp91; Lilrb3; LIR-3; Ly89; Pir; PIR-A1; PIR-B
UniProt ID: (Mouse) P97484
Entrez Gene ID: (Mouse) 18722, (Mouse) 18733
beta-amyloid binding
IgM binding
receptor binding
protein binding
protein phosphatase 1 binding
coreceptor activity
MHC class Ib protein complex binding
MHC class Ib protein binding
HLA-A specific inhibitory MHC class I receptor activity
HLA-B specific inhibitory MHC class I receptor activity
MHC class I receptor activity
MHC class Ib receptor activity
inhibitory MHC class I receptor activity
SH2 domain binding
MHC class I protein binding
protein homodimerization activity
macromolecular complex binding
cell adhesion molecule binding
B cell homeostasis
immune response-inhibiting cell surface receptor signaling pathway
cell surface receptor signaling pathway
learning or memory
cytokine-mediated signaling pathway
B cell mediated immunity
myeloid dendritic cell differentiation
negative regulation of protein metabolic process
regulation of long-term synaptic potentiation
positive regulation of long term synaptic depression
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
