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Invitrogen
PIT1 Recombinant Rabbit Monoclonal Antibody (3Z8F7)
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图: 1 / 6
PIT1 Antibody (MA569768) in IHC (P)
Immunohistochemistry analysis of PIT1 on paraffin-embedded Mouse pituitary tissue. Samples were incubated with PIT1 recombinant monoclonal antibody (Product # MA569768) using a dilution of 1:200 (40x lens). Followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) using a dilution of 1:500 (Red). DAPI was used for nuclear staining (Blue). High pressure antigen retrieval performed with 0. 01M Citr... View More
产品信息
MA569768
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3Z8F7
抗原
Recombinant protein (or fragment).
偶联物
形式
Liquid
浓度
0.89 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3., with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 of mammals, and Unc-86 of C. elegans. PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone and prolactin. PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit by thyrotropin-releasing hormone and cyclic AMP.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GHF-1; Growth hormone factor 1; homeodomain protein for Growth Hormone (GH); PIT-1; Pituary specific transcription factor 1 (growth hormone factor 1); pituitary specific transcription factor 1, related sequence 1; Pituitary-specific positive transcription factor 1; pituitary-specific positive transcription factor 1 variant w; POU domain, class 1, transcription factor 1; POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)
基因别名: dw; dwarf; GHF-1; GHF1; GHF1A; Hmp1; Pit-1; Pit1; Pit1-rs1; PIT1Z; Pou1f1
UniProt ID: (Mouse) Q00286, (Rat) P10037
Entrez Gene ID: (Mouse) 18736, (Rat) 25517
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
RNA polymerase II transcription coactivator activity
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
transcription factor binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
cell fate specification
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
positive regulation of cell proliferation
determination of adult lifespan
pituitary gland development
adenohypophysis development
B cell differentiation
positive regulation of inositol trisphosphate biosynthetic process
positive regulation of multicellular organism growth
regulation of insulin-like growth factor receptor signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
nuclear transport
somatotropin secreting cell differentiation
somatotropin secreting cell development
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