Search Thermo Fisher Scientific
图: 1 / 1
Immunogen sequence: QNKEHFQDEC SKLLVGSIVI TRYNNRTYRI DDVDWNKTPK DSFVMSDGKE ITFLEYYSKN YGITVKEDDQ PLLIHRPSER QNNHGMLLKG EILLLPELSF MTGIPEKMKK DFRAMKDLTQ QINLSPKQHH GALECLLQRI SQNETASNEL TRWGLSLHKD VHKIEGRLLP MERINLRNTS FVTSEDLNWV KEVTRDASIL TIPMHFWALF YPKRAMDQAR ELVNMLEKIA GPIGMRISPP AWVELKDDRI ETYIR
The piwi gene of Drosophila belongs to a novel class of evolutionarily conserved genes (the piwi or Argonaute family). The Piwi family is required for germ and stem cell development in invertebrates, and two Piwi members, MIWI and MILI (Miwi like, Piwil2, Piwi-like protein 2), are essential for spermatogenesis in mouse. MIWI and MILI partner with Piwi-interacting RNAs (piRNAs) which are 26-31 nucleotides in length clearly distinct from the 21-23 nucleotides of microRNAs (miRNAs) or short interfering RNAs (siRNAs). A search for murine small RNAs that might program Piwi proteins for transposon suppression revealed developmentally regulated piRNA loci, some of which resemble transposon master control loci of Drosophila. MILI might be programmed by distinct piRNA populations at different stages of germ cell development, suggesting MILI plays an important role in meiotic prophase progression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Miwi like; Miwi likw; piwi like homolog 2; PIWI-L2; piwi-like 2; piwi-like homolog 2; Piwi-like protein 2
基因别名: Mili; Piwil1l; Piwil2
UniProt ID: (Mouse) Q8CDG1
Entrez Gene ID: (Rat) 306011, (Mouse) 57746