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Invitrogen
PJA2 Polyclonal Antibody
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图: 1 / 2
PJA2 Antibody (PA5-101571) in ICC/IF
Immunofluorescent analysis of PJA2 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and PJA2 polyclonal antibody (Product # PA5-101571) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-101571
产品规格
种属反应
Human,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PJA2(Accession O43164), corresponding to amino acid residues P148-G198.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total PJA2.
靶标信息
Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: KIAA0438; praja 2, RING-H2 motif containing; praja ring finger 2, E3 ubiquitin protein ligase; praja2; ring finger protein 131; RING-type E3 ubiquitin transferase Praja-2; unnamed protein product
基因别名: Neurodap1; RNF131
UniProt ID: (Human) O43164
Entrez Gene ID: (Human) 9867
inflammatory response
long-term memory
protein ubiquitination
positive regulation of toll-like receptor 2 signaling pathway
regulation of macrophage activation
proteasome-mediated ubiquitin-dependent protein catabolic process
innate immune response
positive regulation of JNK cascade
positive regulation of cAMP/PKA signal transduction
positive regulation of p38MAPK cascade
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