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Invitrogen
PKC beta Monoclonal Antibody (K40051_4D2)
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PKC beta Antibody (MA5-55659) in IHC (P)
Immunohistochemistry analysis of PKC beta in paraffin-embedded tonsil tissue. Sample was incubated with PKC beta monoclonal antibody (Product # MA5-55659) at a dilution of 2 µg/mL (RT, 1 hour). Antigen was retrieved through addition of boiling Tris/EDTA buffer pH 9 in a pressure cooker for 3 min. Endogenous peroxidase activity was quenched by incubating the sections with 3% H2O2 for 30 min at room temperatu... View More
产品信息
MA5-55659
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
K40051_4D2
抗原
Recombinant human PRKCB (immunogen range is 171-340).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
产品详细信息
Sequence of this protein is as follows: DVLIVLVRDA KNLVPMDPNG LSDPYVKLKL IPDPKSESKQ KTKTIKCSLN PEWNETFRFQ LKESDKDRRL SVEIWDWDLT SRNDFMGSLS FGISELQKAS VDGWFKLLSQ EEGEYFNVPV PPEGSEANEE LRQKFERAKI SQGTKVPEEK TTNTVSKFDN NGNRDRMKLT
靶标信息
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: PKC-B; PKC-beta; protein kinase C beta I; protein kinase C beta II; Protein kinase C beta type; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide
基因别名: PKC-beta; PKCB; PRKCB; PRKCB1; PRKCB2
UniProt ID: (Human) P05771, (Rat) P68403
Entrez Gene ID: (Human) 5579, (Rat) 25023
chromatin binding
protein serine/threonine kinase activity
protein kinase C activity
calcium-dependent protein kinase C activity
protein kinase C binding
calcium channel regulator activity
protein binding
ATP binding
zinc ion binding
ligand-dependent nuclear receptor transcription coactivator activity
histone kinase activity (H3-T6 specific)
histone binding
androgen receptor binding
non-receptor serine/threonine protein kinase
protein modifying enzyme
response to hypoxia
adaptive immune response
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
calcium ion transport
cellular calcium ion homeostasis
apoptotic process
mitotic nuclear envelope disassembly
signal transduction
negative regulation of glucose transport
peptidyl-serine phosphorylation
platelet activation
positive regulation of vascular endothelial growth factor receptor signaling pathway
histone H3-T6 phosphorylation
intracellular signal transduction
B cell activation
lipoprotein transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of angiogenesis
negative regulation of insulin receptor signaling pathway
B cell receptor signaling pathway
positive regulation of B cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
cellular response to carbohydrate stimulus
response to glucose
regulation of dopamine secretion
dibenzo-p-dioxin metabolic process
response to vitamin D
regulation of growth
positive regulation of odontogenesis of dentin-containing tooth
response to drug
response to ethanol
