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Invitrogen
PKC theta Monoclonal Antibody (M217)
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产品信息
MA5-47677
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
M217
抗原
Clone (M217) was generated from a recombinant mouse PKC theta protein that included amino acids residues in the N-terminal region. This sequence is conserved in human and rat PKC theta, and has low homology to other PKC family members.
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Protein A
保存液
PBS with 1mg/mL BSA, 50% glycerol
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody detects a 79 kDa* protein corresponding to the molecular mass of PKCtheta on SDS-PAGE immunoblots of human Jurkat cell lysates.
靶标信息
Protein Kinase C (PKC) isoforms are serine/threonine kinases involved in signal transduction pathways that govern a wide range of physiological processes including differentiation, proliferation, gene expression, brain function, membrane transport and the organization of cytoskeletal and extracellular matrix proteins. Increasing evidence from studies using in vitro and in vivo systems points to PKC as a key regulator of critical cell cycle transitions, including cell cycle entry and exit and the G1 and G2 checkpoints. PKC-mediated control of these transitions can be negative or positive, depending on the timing of PKC activation during the cell cycle and on the specific PKC isozymes involve. There have been at least 12 different PKC isoforms identified in humans to date, including alpha, beta I, beta II, gamma, delta, epsilon, zeta, eta, theta, iota, lambda, and mu. The different PKC isoforms vary in structure, subcellular localization, tissue distribution and response to extracellular signals. PKC beta II has been shown to be expressed, in part, in cardiac muscle, intestinal epithelium, kidney and pancreas. PKC beta II has been shown to be involved in cell cycle progression and cancer proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EC 2.7.11.13; kinase nPKC-theta; KPCT; MGC126514; MGC141919; nPKC-theta; PKC theta; Protein kinase C theta type; protein kinase C, theta; RP11-563J2.1
基因别名: A130035A12Rik; AW494342; nPKC-theta; PKC-0; PKC-theta; Pkcq; PKCtheta; PRKCQ; PRKCT
UniProt ID: (Human) Q04759, (Mouse) Q02111
Entrez Gene ID: (Human) 5588, (Mouse) 18761, (Rat) 85420
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
protein binding
ATP binding
metal ion binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
regulation of cell growth
response to hypoxia
regulation of transcription, DNA-templated
membrane protein ectodomain proteolysis
cellular component disassembly involved in execution phase of apoptosis
inflammatory response
axon guidance
aging
response to heat
response to glucose
regulation of G2/M transition of mitotic cell cycle
response to organic cyclic compound
peptidyl-serine phosphorylation
regulation of vasoconstriction
platelet activation
positive regulation of telomere maintenance via telomerase
positive regulation of interleukin-17 production
positive regulation of interleukin-4 production
response to insulin
intracellular signal transduction
Fc-epsilon receptor signaling pathway
positive regulation of T cell proliferation
tissue regeneration
positive regulation of NF-kappaB import into nucleus
positive regulation of interleukin-2 biosynthetic process
respiratory burst
negative regulation of insulin receptor signaling pathway
positive regulation of protein secretion
T cell receptor signaling pathway
positive regulation of T cell activation
positive regulation of NF-kappaB transcription factor activity
positive regulation of filopodium assembly
positive regulation of stress fiber assembly
positive regulation of telomerase activity
cell chemotaxis
negative regulation of T cell apoptotic process
regulation of platelet aggregation
positive regulation of telomere capping
positive regulation of T-helper 17 type immune response
positive regulation of T-helper 2 cell activation
immune system process
protein phosphorylation
phosphorylation
neuron differentiation
