Invitrogen

PKD2 Polyclonal Antibody

查看其他13个PKD2抗体

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说明书
实验方案
问题与答案
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说明书
实验方案
问题与答案
技术支持

产品信息

PA5-118167

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-

免疫沉淀 (IP)

1-5 µL/mg of lysate
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

E. coli-derived Human PKD2 fragment

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography, Protein A

保存液

PBS, pH 7

内含物

0.03% ProClin 300

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2902767

靶标信息

This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: A MGC138466; Autosomal dominant polycystic kidney disease type II protein; MGC138468; PC2; polycystic kidney disease 2 (autosomal dominant); Polycystic kidney disease 2 protein; Polycystin-2; Polycystwin; R48321; Transient receptor potential cation channel subfamily P member 2; transient receptor potential cation channel, subfamily P, member 2; TRPP1

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基因别名: APKD2; Pc-2; PC2; PKD2; PKD4; TRPP2

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UniProt ID: (Human) Q13563

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Entrez Gene ID: (Human) 5311

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功能
receptor binding voltage-gated ion channel activity voltage-gated calcium channel activity voltage-gated sodium channel activity potassium channel activity calcium ion binding protein binding cytoskeletal protein binding voltage-gated cation channel activity identical protein binding protein homodimerization activity actinin binding HLH domain binding ion channel binding calcium-induced calcium release activity ATPase binding phosphoprotein binding muscle alpha-actinin binding ion channel
参与通路
branching involved in ureteric bud morphogenesis liver development embryonic placenta development heart looping detection of nodal flow calcium ion transport cell cycle arrest JAK-STAT cascade determination of left/right symmetry heart development negative regulation of cell proliferation spinal cord development neural tube development regulation of cAMP metabolic process positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle cellular response to reactive oxygen species metanephric part of ureteric bud development sodium ion transmembrane transport aorta development regulation of cell proliferation cytoplasmic sequestering of transcription factor positive regulation of nitric oxide biosynthetic process positive regulation of transcription from RNA polymerase II promoter detection of mechanical stimulus release of sequestered calcium ion into cytosol centrosome duplication regulation of postsynaptic membrane potential negative regulation of ryanodine-sensitive calcium-release channel activity placenta blood vessel development renal tubule morphogenesis renal artery morphogenesis calcium ion transmembrane transport positive regulation of cell cycle arrest cellular response to hydrostatic pressure cellular response to osmotic stress cellular response to fluid shear stress potassium ion transmembrane transport determination of liver left/right asymmetry metanephric mesenchyme development mesonephric tubule development mesonephric duct development metanephric smooth muscle tissue development metanephric cortex development metanephric ascending thin limb development metanephric cortical collecting duct development metanephric distal tubule development metanephric S-shaped body morphogenesis regulation of calcium ion import negative regulation of G1/S transition of mitotic cell cycle
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