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Invitrogen
PKN3 Polyclonal Antibody
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产品信息
PA5-100916
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PKN3(Accession Q6P5Z2), corresponding to amino acid residues M447-L497.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total PKN3.
靶标信息
PKN3, a protein kinase C-related molecule, mediates malignant cell growth downstream of activated PI3K. PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 is regulated by PI3K at both the expression level and the catalytic activity level. Therefore, PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Protein kinase PKN-beta; protein kinase PKNbeta; Protein-kinase C-related kinase 3; Serine/threonine-protein kinase N3
基因别名: AW209115; BC034126; LRRGT00147; PKN3; PKNBETA; UTDP4-1
UniProt ID: (Human) Q6P5Z2, (Mouse) Q8K045
Entrez Gene ID: (Human) 29941, (Mouse) 263803, (Rat) 296619
