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Invitrogen
PLA2G4A Polyclonal Antibody
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PLA2G4A Antibody (PA5-99530) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-PLA2G4A (Ser505) in human colon tissues sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-PLA2G4A (Ser505) polyclonal antibody (Product # PA5-99530) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-99530
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PLA2G4A(Accession P47712), corresponding to amino acid residues F479-D529.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total c-PLA2.
靶标信息
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: calcium-dependent phospholipid-binding protein; cPLA2; cytosolic group IVA; Cytosolic phospholipase A2; group IVA; lysophospholipase; MGC126350; phosphatidylcholine 2-acylhydrolase; phospholipase A2 cytosolic; Phospholipase A2 group IVA; phospholipase A2, group IVA (cytosolic, calcium-dependent)
基因别名: CPLA2; cPLA2-alpha; cPLA2alpha; Pla2c; PLA2G4; PLA2G4A
UniProt ID: (Human) P47712, (Mouse) P47713
Entrez Gene ID: (Human) 5321, (Mouse) 18783, (Rat) 24653
ovulation from ovarian follicle
luteolysis
phospholipid metabolic process
phosphatidic acid biosynthetic process
platelet activating factor biosynthetic process
icosanoid metabolic process
aging
positive regulation of cell proliferation
phospholipid catabolic process
response to heat
response to lithium ion
response to organonitrogen compound
arachidonic acid metabolic process
positive regulation of bone mineralization
positive regulation of vesicle fusion
positive regulation of prostaglandin biosynthetic process
positive regulation of fever generation
response to lipopolysaccharide
response to vitamin D
cardiolipin acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
response to hydrogen peroxide
positive regulation of apoptotic process
surfactant homeostasis
icosanoid biosynthetic process
decidualization
arachidonic acid secretion
response to glucocorticoid
response to calcium ion
response to methylmercury
cellular response to antibiotic
response to hormone
response to organic substance
regulation of cell proliferation
positive regulation of inflammatory response
