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Invitrogen
PLAGL2 Polyclonal Antibody
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产品信息
PA5-100303
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PLAGL2(Accession Q9UPG8), corresponding to amino acid residues R28-A78.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total PLAGL2.
靶标信息
The PLAG (Pleiomorphic adenoma gene) family of zinc finger proteins include PLAG1, ZAC1 and PLAG-like 2 (PLAGL2). PLAG1 is the target gene for the pleiomorphic adenomas of the salivary gland. ZAC1 (PLAGL1) concomitantly controls apoptosis and cell cycle arrest through separate pathways. ZAC1 also acts as a transcriptional cofactor for nuclear receptors. PLAGL2 belongs to the krueppel C2H2-type zinc-finger protein family and contains 6 C2H2-type zinc fingers. It functions as a positive regulator of transcription and localizes to the nucleus. PLAGL2 is ubiquitously expressed with particular abundance in spleen, lung and testis, where it may be involved in cell cycle arrest and apoptosis of tumor cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C2H2-type zinc finger protein; pleiomorphic adenoma gene-like 2; Pleiomorphic adenoma-like protein 2; pleomorphic adenoma gene like 2; Zinc finger protein PLAGL2
基因别名: AU018672; AW552839; KIAA0198; mKIAA0198; PLAGL2; ZNF900
UniProt ID: (Human) Q9UPG8
Entrez Gene ID: (Human) 5326, (Mouse) 54711, (Rat) 296281
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
metal ion binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
C2H2 zinc finger transcription factor
transcription from RNA polymerase II promoter
lipid metabolic process
post-embryonic development
chylomicron assembly
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein targeting to mitochondrion
positive regulation of intrinsic apoptotic signaling pathway
regulation of transcription from RNA polymerase II promoter
