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Immunogen sequence: KSHSQELLKI KTEPVDMLGL LSCSSTVSVK EELSPVLCMA SRDVMGTKAF PGMLPMGMYG AHIPTMPSTG VPHSLVHNTL PMGMSYPLES SPISSPAQLP PKYQLGSTSY LPDKLPKVEV DSFLAELPGS LSLSSAEPQP ASPQPAAAAA LLDEALLAKS PANLSEALCA ANVDFSHLLG FLPLNLPPCN PPGATGGLVM GYSQAEAQPL LTTLQAQPQD SPGAGGPLNF G
The PLAG (Pleiomorphic adenoma gene) family of zinc finger proteins include PLAG1, ZAC1 and PLAG-like 2 (PLAGL2). PLAG1 is the target gene for the pleiomorphic adenomas of the salivary gland. ZAC1 (PLAGL1) concomitantly controls apoptosis and cell cycle arrest through separate pathways. ZAC1 also acts as a transcriptional cofactor for nuclear receptors. PLAGL2 belongs to the krueppel C2H2-type zinc-finger protein family and contains 6 C2H2-type zinc fingers. It functions as a positive regulator of transcription and localizes to the nucleus. PLAGL2 is ubiquitously expressed with particular abundance in spleen, lung and testis, where it may be involved in cell cycle arrest and apoptosis of tumor cells.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: C2H2-type zinc finger protein; pleiomorphic adenoma gene-like 2; Pleiomorphic adenoma-like protein 2; Zinc finger protein PLAGL2
基因别名: KIAA0198; PLAGL2; ZNF900
UniProt ID: (Human) Q9UPG8
Entrez Gene ID: (Human) 5326