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Invitrogen
PLD2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-104015
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PLD2(Accession O14939), corresponding to amino acid residues P486-P536.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total PLD2.
靶标信息
PLD2 is a peripheral membrane protein belonging to phospholipase D family with a PH domain, two PLD phosphodiesterase domains and a PX (phox homology) domain that plays a regulatory rather than catalytic role. PLD2 catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid and choline. PLD2 may function in regulated secretion, signal-induced cytoskeletal regulation and/or endocytosis, transcriptional regulation, and cell cycle control. It is usually stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and activated by the ADP-ribosylation factor-1 (ARF-1). PLD2 is activated by agonist stimulation of both tyrosine kinase and G protein-coupled receptors and is also known to interact with EGFR and PIP5K1A. PLD2, localized to plasma membrane caveolae, is ubiquitously expressed in most tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Choline phosphatase 2; Phosphatidylcholine-hydrolyzing phospholipase D2; phospholipase D gene 2; Phospholipase D2; PLD 2; PLD1C; rPLD2
基因别名: PLD1C; PLD2; Pldc
UniProt ID: (Mouse) P97813, (Rat) P70498
Entrez Gene ID: (Mouse) 18806, (Rat) 25097
response to hypoxia
G-protein coupled receptor internalization
receptor-mediated endocytosis
phospholipid catabolic process
positive regulation of phosphatidylinositol 3-kinase signaling
response to organic cyclic compound
positive regulation of cell migration
neuron projection development
response to hydrogen peroxide
positive regulation of mast cell degranulation
response to peptide hormone
positive regulation of cell adhesion
positive regulation of receptor-mediated endocytosis
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