Invitrogen

PLK5 Polyclonal Antibody

Name: PLK5 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-57120

高级验证

查看其他6个PLK5抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)
高级验证 (1)

PLK5 Antibody in Immunohistochemistry (IHC)

图: 1 / 4

PLK5 Antibody (PA5-57120) in IHC

Immunohistochemical staining of PLK5 in human testis and tonsil tissues using PLK5 Polyclonal Antibody (Product # PA5-57120). Corresponding PLK5 RNA-seq data are presented for the same tissues.

Product Image Gallery

PLK5 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of PLK5 demonstrates antibody specificity. Immunohistochemical analysis of PLK5 using anti-PLK5 Polyclonal Antibody (Product # PA5-57120), shows significant staining of PLK5 in human testis and shows minimal or weak staining in human tonsil tissues. The relative expression levels of PLK5 within each tissue is shown using RNA-Seq. {RE}

Immunogen image

Immunogen Image PLK5 Polyclonal Antibody

产品信息

PA5-57120

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:200-1:500

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human PLK5. Recombinant protein control fragment (Product #RP-97250).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.3 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2645676

产品详细信息

Immunogen sequence: YTVLTGTPPF MASPLSEMYQ NIREGHYPEP AHLSANARRL IVHLLAPNPA ERPSLDHLLQ DDFFTQ

Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 79%.

靶标信息

Polo-like kinase 5 (PLK5) is a member of the Polo-like kinase family, notable for its involvement in cell cycle regulation processes such as mitotic entry, spindle formation, and cytoplasmic division. PLK5 is distinguished from other family members by its low expression levels, particularly within different immunophenotypes, except for being notably elevated in the C5 subtype. Its expression has been linked to poor prognosis in non-small cell lung cancer, although this is not universally supported by all data sources, suggesting complex roles in tumor biology. In a mouse model, PLK5 functions as a DNA damage-inducible gene with nucleolar localization, facilitated by a specific nucleolus localization signal in its N-terminal. The protein's ectopic expression can lead to G1 phase arrest, indicating its role in cellular response to DNA damage. Research is ongoing to fully elucidate its function and prognostic implications across various cancer types.

仅用于科研。不用于诊断过程。未经明确授权不得转售。