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Immunogen sequence: ELPRTPLLDE EEEENPDKAS KFGTRVLLLD GEVTPYANTN NNAVDCNQVQ LPQSDSSLQS LETSV; Positive Samples: Mouse brain; Cellular Location: Cell membrane, Cell projection, Multi-pass membrane protein, cilium, flagellum membrane
The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/K+ pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin (Cat. # MA3-917 and MA3-918).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Plasma membrane calcium-transporting ATPase 4; PMCA4
基因别名: Atp2b4; Pmca4
UniProt ID: (Mouse) Q6Q477
Entrez Gene ID: (Mouse) 381290