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Invitrogen

PML Polyclonal Antibody

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View all (21) PML antibodies

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PML Polyclonal Antibody

Product Details

PA5-51039

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (IHC)

1:100-1:300
-

Immunocytochemistry (ICC/IF)

1:200-1:1,000
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthesized peptide derived from the N-terminal region of human PML.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 0.5% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2636487

Product Specific Information

PML Polyclonal Antibody detects endogenous levels of PML protein.

Target Information

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: E3 SUMO-protein ligase PML; My1 (PML); PML; PML/RARA fusion; pml1; probable transcription factor PML; Promyelocytic leukemia protein; promyelocytic leukemia, inducer of; Protein PML; putative; RING finger protein 71; RING-type E3 SUMO transferase PML; TRIM19; tripartite motif protein TRIM19; Tripartite motif-containing protein 19; unnamed protein product

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Gene Aliases: MYL; PML; PP8675; RNF71; TRIM19

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UniProt ID: (Human) P29590

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Entrez Gene ID: (Human) 5371

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Function(s)
DNA binding transcription coactivator activity protein binding zinc ion binding transferase activity SUMO transferase activity ubiquitin protein ligase binding SUMO binding identical protein binding protein homodimerization activity SMAD binding metal ion binding protein heterodimerization activity cobalt ion binding binding, bridging ubiquitin-like protein ligase activity
Process(es)
response to hypoxia positive regulation of defense response to virus by host immune system process chromatin remodeling regulation of transcription, DNA-templated protein targeting protein import into nucleus apoptotic process transforming growth factor beta receptor signaling pathway negative regulation of cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to oxidative stress response to UV response to gamma radiation regulation of calcium ion transport into cytosol negative regulation of gene expression fibroblast migration negative regulation of angiogenesis protein sumoylation myeloid cell differentiation regulation of cell adhesion negative regulation of cell growth DNA damage response, signal transduction by p53 class mediator PML body organization protein complex localization positive regulation of telomere maintenance negative regulation of telomere maintenance via telomerase endoplasmic reticulum calcium ion homeostasis negative regulation of interleukin-1 beta production negative regulation of interleukin-1 production circadian regulation of gene expression negative regulation of translation in response to oxidative stress response to cytokine protein localization to nucleus regulation of circadian rhythm intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator entrainment of circadian clock by photoperiod proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation by host of viral release from host cell innate immune response cell fate commitment establishment of protein localization negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of fibroblast proliferation retinoic acid receptor signaling pathway rhythmic process protein stabilization regulation of protein metabolic process maintenance of protein location in nucleus defense response to virus regulation of cell cycle positive regulation of apoptotic process involved in mammary gland involution regulation of cellular localization SMAD protein signal transduction branching involved in mammary gland duct morphogenesis protein-containing complex assembly regulation of biological quality intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to interleukin-4 intrinsic apoptotic signaling pathway by p53 class mediator cellular senescence oncogene-induced cell senescence extrinsic apoptotic signaling pathway positive regulation of signal transduction by p53 class mediator positive regulation of protein localization to chromosome, telomeric region cellular response to leukemia inhibitory factor negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process regulation of double-strand break repair positive regulation of apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway
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