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Invitrogen
PNP Polyclonal Antibody
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Product Details
PA5-51616
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PNP. Recombinant protein control fragment (Product #RP-98841).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: YTYEDYKNTA EWLLSHTKHR PQVAIICGSG LGGLTDKLTQ AQIFDYGEIP NFPRSTVPGH AGRLVFGFLN GRACVMMQGR FHMYEGYPLW KVTFPVRVFH LLGVDTLVVT NAAGGLNPKF EVGDIMLIRD HINLPGFSGQ NPLRGPNDER GAPHR
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 87%.
Target Information
The PNP gene encodes for the enzyme purine nucleoside phosphorylase, which plays a vital role in the purine salvage pathway by catalyzing the reversible cleavage of purine nucleosides. This enzyme facilitates the conversion of inosine, guanosine, and deoxyguanosine into free bases and sugars phosphorylated at the C1 position. PNP is located on chromosome 14q13 and is crucial for nucleoside catabolism, impacting energy metabolism and cellular functions across various organisms. PNP deficiency is an autosomal recessive multisystem disorder arising from mutations in the PNP gene, leading to impaired T-cell maturation and function, resulting in recurrent infections, autoimmune manifestations, and neurological abnormalities due to the toxic accumulation of deoxyguanosine triphosphate (dGTP). This deficiency particularly affects immature thymocytes and can lead to lymphoid and neuronal toxicity, underscoring the gene's importance in proper immune system function and cellular health.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein Li 156an; HEL-S-156an; Inosine phosphorylase; inosine phosphorylase {ECO:0000250|UniProtKB:P00491}; Inosine-guanosine phosphorylase; nucleoside phosphorylase; PNP; PNP {ECO:0000250|UniProtKB:P00491}; Purine nucleoside phosphorylase; purine nucleoside phosphorylase {ECO:0000250|UniProtKB:P00491}; purine-nucleoside phosphorylase 1; purine-nucleoside:orthophosphate ribosyltransferase
Gene Aliases: AL024301; AU015798; NP; Np-1; Np-2; PNP; Pnp1; PRO1837; PUNP
UniProt ID: (Human) P00491, (Mouse) P23492
Entrez Gene ID: (Human) 4860, (Mouse) 18950, (Rat) 290029
nucleoside binding
purine nucleobase binding
purine-nucleoside phosphorylase activity
drug binding
phosphate ion binding
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring pentosyl groups
kinase
nucleotide kinase
transferase
metabolite interconversion enzyme
nucleobase-containing compound metabolic process
inosine catabolic process
purine nucleotide catabolic process
nicotinamide riboside catabolic process
immune response
NAD biosynthesis via nicotinamide riboside salvage pathway
urate biosynthetic process
positive regulation of T cell proliferation
response to drug
purine-containing compound salvage
positive regulation of alpha-beta T cell differentiation
interleukin-2 secretion
positive regulation of T cell mediated cytotoxicity
deoxyinosine catabolic process
deoxyguanosine catabolic process
GTP biosynthetic process
intrinsic apoptotic signaling pathway in response to DNA damage
apoptotic mitochondrial changes
nucleoside metabolic process
response to gamma radiation
purine nucleoside metabolic process
positive regulation of B cell differentiation
positive regulation of DNA repair
dGTP metabolic process
guanosine catabolic process
negative regulation of T cell apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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