Abnova

PPARA Monoclonal Antibody (1A8)

查看其他14个PPAR alpha抗体

问题与答案

问题与答案

问题与答案

Additional Information:

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产品信息

H00005465-M03

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

10-100 µg/mL

-

酶联免疫吸附实验 (ELISA)

10 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

1A8

抗原

PPARA (AAH00052, 1 a.a. approximately 258 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Immunogen sequence: MVDTESPLCP LSPLEAGDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFG FTEYQYLGSC PGSDGSVITD TLSPASSPSS VTYPVVPGSV DESPSGALNI ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR NKCQYCRFHK CLSVGRSHNA IRFGRMPRSE KAKLKAEILT CEHDIEDSET ADLKSLAKRI YEAYLKNFNM NKVKARVILS GKASNNPVGV CGCSGFSWQH GTSVVEDD

靶标信息

Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed peroxisome proliferator activated receptors (PPAR's). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPAR's are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPAR's can induce transcription of acyl coenzyme A oxidase & cytochrome P450 (CYP450) A6 through interaction with specific response elements. PPAR, like several other nuclear hormone receptors, heterodimerizes with retinoid X receptor (RXR) alpha.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: MGC2237; MGC2452; Nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha; peroxisome proliferator; peroxisome proliferator activated receptor; Peroxisome proliferator-activated receptor alpha; PPAR-alpha; PPARA; PPARalpha; unnamed protein product

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基因别名: hPPAR; NR1C1; PPAR; PPAR-alpha; PPARA; PPARalpha

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UniProt ID: (Human) Q07869

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Entrez Gene ID: (Human) 5465

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RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding transcription coactivator binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding lipid binding phosphatase binding protein domain specific binding mitogen-activated protein kinase kinase kinase binding ubiquitin conjugating enzyme binding signaling receptor activity sequence-specific DNA binding macromolecular complex binding metal ion binding NFAT protein binding RNA polymerase II sequence-specific DNA binding transcription factor binding MDM2/MDM4 family protein binding DNA-binding transcription factor binding

negative regulation of transcription from RNA polymerase II promoter response to hypoxia gluconeogenesis regulation of transcription, DNA-templated lipid metabolic process fatty acid metabolic process heart development response to nutrient lactation epidermis development cellular response to starvation hormone-mediated signaling pathway gene expression regulation of gene expression regulation of cellular ketone metabolic process negative regulation of macrophage derived foam cell differentiation negative regulation of cholesterol storage regulation of fatty acid metabolic process cell differentiation negative regulation of transforming growth factor beta receptor signaling pathway intracellular steroid hormone receptor signaling pathway intracellular receptor signaling pathway positive regulation of fatty acid beta-oxidation negative regulation of appetite response to insulin circadian regulation of gene expression behavioral response to nicotine peroxisome proliferator activated receptor signaling pathway wound healing lipoprotein metabolic process regulation of circadian rhythm response to ethanol positive regulation of gluconeogenesis negative regulation of blood pressure negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of fatty acid metabolic process positive regulation of transcription from RNA polymerase II promoter nitric oxide metabolic process positive regulation of fatty acid oxidation positive regulation of lipid biosynthetic process rhythmic process negative regulation of inflammatory response negative regulation of protein kinase B signaling negative regulation of cell growth involved in cardiac muscle cell development enamel mineralization cellular response to fructose stimulus negative regulation of cytokine production involved in inflammatory response negative regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of leukocyte cell-cell adhesion negative regulation of reactive oxygen species biosynthetic process negative regulation of hepatocyte apoptotic process positive regulation of transformation of host cell by virus regulation of fatty acid transport positive regulation of ATP biosynthetic process