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Invitrogen
PPIP5K2 Polyclonal Antibody
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产品信息
PA5-114049
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the middle region of human HISPPD1
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SLSSCQQRVK ARLHEILQKD RDFTAEDYEK LTPSGSISLI KSMHLIKNPV
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 93%
靶标信息
PPIP5K2, also known as inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinase 2, is a gene located on chromosome 5 in humans. This gene encodes a kinase involved in the phosphorylation of inositol pyrophosphates, which are essential for cellular signaling and regulation processes. Specifically, PPIP5K2 phosphorylates InsP6 and 1-InsP7 at the 5 position, playing a significant role in both cellular proliferation and metastasis. Recent studies have shown that PPIP5K2 can facilitate the growth and spread of non-small lung cancer (NSCLC) and colorectal carcinoma. It promotes cellular proliferation and migration independent of its kinase activity, in part by modifying its interaction with proteins like 14-3-3, affecting its subcellular distribution. Structural analysis of PPIP5K2 reveals that it possesses unique kinetic properties distinct from other inositol kinase isoforms. Genetic variants, such as the Arg837His missense variant, can alter its phosphatase activity, potentially impacting its functionality in signaling pathways. PPIP5K2 is intricately involved in epithelial-mesenchymal transition (EMT) mechanisms, further influencing cancer cell metastasis. Understanding the biochemical pathways and genetic variations associated with PPIP5K2 is crucial in comprehending its role in disease pathogenesis and therapeutic targeting.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Diphosphoinositol pentakisphosphate kinase 2; Histidine acid phosphatase domain-containing protein 1; hsVIP2; inositol heptaphosphate kinase 2; Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2; InsP6 and PP-IP5 kinase 2; VIP1 homolog 2
基因别名: CFAP160; HISPPD1; IP7K2; KIAA0433; PPIP5K2; VIP2
UniProt ID: (Human) O43314
Entrez Gene ID: (Human) 23262
inositol-1,3,4,5,6-pentakisphosphate kinase activity
inositol hexakisphosphate kinase activity
inositol heptakisphosphate kinase activity
inositol hexakisphosphate 5-kinase activity
acid phosphatase activity
ATP binding
diphosphoinositol-pentakisphosphate kinase activity
inositol hexakisphosphate 1-kinase activity
inositol hexakisphosphate 3-kinase activity
nucleotide kinase
