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Invitrogen
PPP1R8 Polyclonal Antibody
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产品信息
PA5-87274
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length Human NIPP1.
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activator of RNA decay; ard-1; NIPP-1; NIPP1-T; Nuclear inhibitor of protein phosphatase 1; nuclear inhibitor of protein phosphatase-1 alpha; nuclear inhibitor of protein phosphatase-1 beta; nuclear subunit of PP-1; PPP1R8; Protein phosphatase 1 regulatory inhibitor subunit 8; protein phosphatase 1, regulatory (inhibitor) subunit 8; RNase E; unnamed protein product
基因别名: 6330548N22Rik; ARD-1; ARD1; AU044684; NIPP-1; NIPP1; PPP1R8; PRO2047
UniProt ID: (Human) Q12972, (Mouse) Q8R3G1
Entrez Gene ID: (Human) 5511, (Rat) 313030, (Mouse) 100336
DNA binding
RNA binding
mRNA binding
nuclease activity
endonuclease activity
endoribonuclease activity
protein phosphatase inhibitor activity
protein serine/threonine phosphatase inhibitor activity
protein binding
ribonuclease E activity
hydrolase activity
protein phosphatase regulator activity
molecular function inhibitor activity
protein phosphatase type 1 regulator activity
RNA splicing factor
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