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Invitrogen
PPP2R1A Polyclonal Antibody
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产品信息
PA5-17516
产品规格
种属反应
Fruit fly,
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the carboxy terminus of human PP2A A subunit
偶联物
形式
Liquid
浓度
33 µg/mL
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other PP2A subunits.
靶标信息
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 65 kDa regulatory subunit of protein phosphatase; alpha isoform of regulatory subunit A, protein phosphatase 2; CG17291-PA; CG17291-PB; CG17291-PC; CG17291-PD; CG17291-PE; Medium tumor antigen-associated 61 kDa protein; MGC786; PP2A 65kD subunit A; PP2A subunit A isoform PR65-alpha; PP2A subunit A isoform R1-alpha; Pp2A-29B-PA; Pp2A-29B-PB; Pp2A-29B-PC; Pp2A-29B-PD; Pp2A-29B-PE; PP2Ac; PP2CA; PP2Calpha; PR65; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform; protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform; protein phosphatase 2 regulatory subunit A, alpha; protein phosphatase 2, regulatory subunit A, alpha; protein phosphatase 2A; protein phosphatase PP2A; Protein phosphatase PP2A regulatory subunit A; protein phosphate 2A; regulatory subunit A of type 2A protein phosphatase; RP-C; serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform; serine/threonine protein phosphatase A subunit type 2A; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit; testicular secretory protein Li 1
基因别名: 29B; 6330556D22Rik; A/PR65; CG13383; CG17291; CG33297; Dmel\CG17291; Dmel_CG17291; dPP2A A; DPR65; MRD36; PP2A; PP2A 29B; PP2A A; PP2A-29B; PP2A-A; PP2A-Aalpha; Pp2A29B; PP2A[A]; PP2AAALPHA; PPP2R1A; PR65; PR65A
UniProt ID: (Human) P30153, (Fruit fly) P36179, (Mouse) Q76MZ3
Entrez Gene ID: (Human) 5518, (Fruit fly) 2768940, (Mouse) 51792, (Rat) 117281
G2/M transition of mitotic cell cycle
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
inactivation of MAPK activity
regulation of DNA replication
regulation of transcription, DNA-templated
protein complex assembly
protein dephosphorylation
ceramide metabolic process
apoptotic process
chromosome segregation
mitotic nuclear envelope reassembly
female meiotic division
RNA splicing
response to organic substance
second-messenger-mediated signaling
regulation of Wnt signaling pathway
regulation of cell adhesion
negative regulation of cell growth
regulation of protein phosphatase type 2A activity
regulation of growth
negative regulation of tyrosine phosphorylation of Stat3 protein
regulation of cell differentiation
meiotic spindle elongation
mitotic sister chromatid separation
meiotic sister chromatid cohesion, centromeric
peptidyl-serine dephosphorylation
regulation of meiotic cell cycle process involved in oocyte maturation
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
autophagy
centrosome cycle
centriole replication
negative regulation of hippo signaling
negative regulation of smoothened signaling pathway
negative regulation of insulin receptor signaling pathway
spindle assembly
