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Invitrogen
PR3 Recombinant Rabbit Monoclonal Antibody (K01_4L31)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA567318
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_4L31
抗原
A synthesized peptide derived from human PR3.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 150mM NaCl, 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: azurophil granule protein 7; C-ANCA antigen; leukocyte proteinase 3; neutrophil proteinase 4; serine proteinase, neutrophil; unnamed protein product; wegener autoantigen; Wegener granulomatosis autoantigen
基因别名: ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3
UniProt ID: (Human) P24158
Entrez Gene ID: (Human) 5657
proteolysis
membrane protein ectodomain proteolysis
positive regulation of cell proliferation
antimicrobial humoral response
positive regulation of GTPase activity
cell-cell junction maintenance
negative regulation of phagocytosis
neutrophil extravasation
mature conventional dendritic cell differentiation
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