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Invitrogen
PRDM8 Polyclonal Antibody
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Product Details
PA5-28414
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human PRDM8. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HCT116.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3. Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR. Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation. In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PFM5; PR domain 8; PR domain zinc finger protein 8; PR domain-containing protein 8; PR-domain containing protein 8; unnamed protein product
Gene Aliases: EPM10; KMT8D; PFM5; PRDM8
UniProt ID: (Human) A8K7X2
Entrez Gene ID: (Human) 56978
chromatin remodeling
regulation of transcription, DNA-templated
nervous system development
oligodendrocyte development
corpus callosum morphogenesis
central nervous system projection neuron axonogenesis
corticospinal tract morphogenesis
neurogenesis
methylation
negative regulation of transcription, DNA-templated
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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