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产品信息
PA5-116556
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 63-256 of human Peroxiredoxin 3 (Peroxiredoxin 3 (PRDX3)) (NP_0067841)
偶联物
形式
Liquid
浓度
1.01 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901187
产品详细信息
Positive Samples: U-87MG, HeLa, LO2, A-549, Mouse kidney
Immunogen sequence: PAVTQHAPYF KGTAVVNGEF KDLSLDDFKG KYLVLFFYPL DFTFVCPTEI VAFSDKANEF HDVNCEVVAV SVDSHFSHLA WINTPRKNGG LGHMNIALLS DLTKQISRDY GVLLEGSGLA LRGLFIIDPN GVIKHLSVND LPVGRSVEET LRLVKAFQYV ETHGEVCPAN WTPDSPTIKP SPAASKEYFQ KVNQ
靶标信息
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: anti-oxidant protein 1; antioxidant protein; Antioxidant protein 1; AOP-1; HBC189; mitochondrial thioredoxin dependent peroxide reductase; mitochondrial Trx dependent peroxide reductase; Perioredoxin-3; Peroxiredoxin III; Peroxiredoxin-3; Protein MER5; Protein MER5 homolog; Prx 3; PRX III; PRX-3; Prx-III; Thioredoxin-dependent peroxide reductase, mitochondrial; Thioredoxin-dependent peroxiredoxin 3
基因别名: AOP-1; AOP1; AW822249; D0Tohi1; Ef2l; HBC189; MER5; PRDX3; PRO1748; prx-III; Prx3; SP-22; SP22; TDXM
UniProt ID: (Human) P30048, (Mouse) P20108, (Rat) Q9Z0V6
Entrez Gene ID: (Human) 10935, (Mouse) 11757, (Rat) 64371
protein binding
protein C-terminus binding
thioredoxin peroxidase activity
alkyl hydroperoxide reductase activity
kinase binding
protein kinase binding
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
peroxidase activity
antioxidant activity
oxidoreductase activity
peroxiredoxin activity
molecular_function
peroxidase
response to reactive oxygen species
maternal placenta development
apoptotic process
response to oxidative stress
mitochondrion organization
positive regulation of cell proliferation
peptidyl-cysteine oxidation
myeloid cell differentiation
response to lipopolysaccharide
negative regulation of kinase activity
cellular response to oxidative stress
cellular response to reactive oxygen species
response to hydrogen peroxide
hydrogen peroxide catabolic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
cell redox homeostasis
positive regulation of NF-kappaB transcription factor activity
regulation of mitochondrial membrane potential
cellular oxidant detoxification
negative regulation of neuron apoptotic process
oxidation-reduction process
