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Immunogen sequence: TKQISRDYGV LLEGSGLALR GLFIIDPNGV IKHLSV
Antigen sequence identity: Mouse 89%; Rat 92%
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Antioxidant protein 1; AOP-1; HBC189; Peroxiredoxin III; Peroxiredoxin-3; Protein MER5 homolog; Prx 3; Prx-III; Thioredoxin-dependent peroxide reductase, mitochondrial; Thioredoxin-dependent peroxiredoxin 3
基因别名: AOP-1; AOP1; HBC189; MER5; PRDX3; PRO1748; prx-III; SP-22
UniProt ID: (Human) P30048
Entrez Gene ID: (Human) 10935