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Invitrogen
PREB Polyclonal Antibody
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产品信息
PA5-53066
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: REAHGIVVTD VAFLPEKGRG PELLGSHETA LFSVAVDSRC QLHLLPSRRS VP
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.
靶标信息
Prolactin (PRL) expression in the pituitary is limited to specific cells. Pit-1 is a pituitary specific transcription factor that plays an important role in PRL expression, both in mature organism and during development. The PRL promoter contains numerous Pit-1 binding sites and these sites have been implicated in both basal level and kinase-mediated gene expression. The most proximal of these binding sites, termed 1P, has been shown to direct a response to numerous signals, such as cAMP and various G-proteins. A novel protein, termed PREB (prolactin regulatory element binding protein), has been recently identified that regulates PRL gene expression through the 1P site, though it contains no discernable DNA-binding motif. Recent studies suggest that PREB is encoded by a single-copy gene in both mice and humans and exhibits nuclear accumulation in pituitary cells. Evidence suggests that PREB is a novel transcription factor that assists in PRL expression whether alone, or in concert with Pit-1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Guanine nucleotide-exchange factor SEC12; mammalian guanine nucleotide exchange factor mSec12; Mammalian guanine nucleotide exchange factor Sec12; mSec12; prolactin regulatory binding-element protein; Prolactin regulatory element-binding protein
基因别名: C85705; PREB; SEC12
UniProt ID: (Human) Q9HCU5, (Rat) Q9WTV0, (Mouse) Q9WUQ2
Entrez Gene ID: (Human) 10113, (Rat) 58842, (Mouse) 50907
DNA binding
guanyl-nucleotide exchange factor activity
Sar guanyl-nucleotide exchange factor activity
protein binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
guanyl-nucleotide exchange factor
transcription, DNA-templated
regulation of transcription, DNA-templated
ER to Golgi vesicle-mediated transport
protein exit from endoplasmic reticulum
IRE1-mediated unfolded protein response
positive regulation of GTPase activity
COPII vesicle coating
protein transport
vesicle-mediated transport
positive regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transport
