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Invitrogen
PREX1 Polyclonal Antibody
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PREX1 Antibody (PA5-34961) in IHC (P)
PREX1 Polyclonal Antibody detects PREX1 protein at cytosol on HeLa xenograft by immunohistochemical analysis. Sample: Paraffin-embedded HeLa xenograft. PREX1 Polyclonal Antibody (Product # PA5-34961) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-34961
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human PREX1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: THP-1, human PREX1-transfected 293T cells.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: OTTHUMP00000031228; P-Rex1; Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1; PIP3 dependent Rac exchange factor 1; PREX 1; PREX-1; ptdIns(3,4,5)-dependent Rac exchanger 1
基因别名: KIAA1415; P-REX1; PREX1
UniProt ID: (Human) Q8TCU6
Entrez Gene ID: (Human) 57580
superoxide metabolic process
G-protein coupled receptor signaling pathway
actin filament polymerization
T cell differentiation
neutrophil chemotaxis
regulation of actin filament polymerization
regulation of Rho protein signal transduction
intracellular signal transduction
neutrophil activation
positive regulation of GTPase activity
regulation of dendrite development
positive regulation of substrate adhesion-dependent cell spreading
