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Abnova
PRICKLE1 Monoclonal Antibody (8G5)
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产品信息
H00144165-M02
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
8G5
抗原
PRICKLE1 (NP_694571, 684 a.a. approximately 756 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.45 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: DNALNLVTER KYSPKDRLRL YTPDNYEKFI QNKSAREIQA YIQNADLYGQ YAHATPDYGL QNPGMNRFLG LYG
靶标信息
Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: prickle homolog 1; prickle-like 1; Prickle-like protein 1; REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein; REST/NRSF interacting LIM domain protein; REST/NRSF-interacting LIM domain protein 1
基因别名: EPM1B; PRICKLE1; RILP
UniProt ID: (Human) Q96MT3
Entrez Gene ID: (Human) 144165
neural tube closure
protein import into nucleus
positive regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
aorta development
negative regulation of transcription, DNA-templated
Wnt signaling pathway, planar cell polarity pathway
coronary vasculature development
negative regulation of canonical Wnt signaling pathway
negative regulation of cardiac muscle cell myoblast differentiation
