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Abnova
PRKCA Recombinant Rabbit Monoclonal Antibody
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PRKCA Antibody (RAB01670) in IHC (P)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon cancer with Phospho-PKC alpha (Thr638) recombinant monoclonal antibody, clone R09-7C7 (Product # RAB01670). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
产品信息
RAB01670
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Synthetic phosphopeptide corresponding to residues surrounding Thr638 of human PKC alpha.
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
50mM tris glycine, pH 7.4, with 40% glycerol, 150mM NaCl, 0.05% BSA
内含物
0.01% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
The PKC family of serine/threonine kinases, including PRKCA (PKC alpha), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; EC 2.7.11.13; FHC; FTH; FTHL6; kinase PKC-alpha; KPCA; MGC104426; PIG15; PKA C-alpha; PKC III; PKC-III; PLIF; protein kinase A catalytic subunit; protein kinase, cAMP-dependent, alpha catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha
基因别名: PKACA; PPNAD4; PRKACA
UniProt ID: (Human) P17612
Entrez Gene ID: (Human) 5566
protein serine/threonine kinase activity
cAMP-dependent protein kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
protein kinase binding
ubiquitin protein ligase binding
protein complex binding
protein kinase A regulatory subunit binding
non-receptor serine/threonine protein kinase
G2/M transition of mitotic cell cycle
mesoderm formation
neural tube closure
regulation of heart rate
stimulatory C-type lectin receptor signaling pathway
renal water homeostasis
mRNA processing
protein phosphorylation
blood coagulation
positive regulation of cell proliferation
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
activation of protein kinase A activity
calcium-mediated signaling using intracellular calcium source
lipoprotein metabolic process
regulation of protein binding
regulation of cellular respiration
regulation of osteoblast differentiation
protein autophosphorylation
positive regulation of protein export from nucleus
sperm capacitation
negative regulation of meiotic cell cycle
regulation of cytosolic calcium ion concentration
regulation of synaptic transmission, glutamatergic
regulation of cardiac muscle contraction
regulation of ryanodine-sensitive calcium-release channel activity
regulation of proteasomal protein catabolic process
regulation of protein processing
positive regulation of cell cycle arrest
cellular response to glucose stimulus
cellular response to parathyroid hormone stimulus
cellular response to glucagon stimulus
cellular response to epinephrine stimulus
cell communication by electrical coupling involved in cardiac conduction
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
regulation of cardiac conduction
regulation of bicellular tight junction assembly
