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Invitrogen
PRL3 Polyclonal Antibody
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FIGURE: 1 / 4
PRL3 Antibody (PA5-106905) in ICC/IF
Immunocytochemistry analysis of PRL3 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with PRL3 polyclonal antibody (Product # PA5-106905) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-106905
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PTP4A3(Accession O75365), corresponding to amino acid residues R137-M173.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PTP4A3.
Target Information
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. PRL-3 expression was found to be up-regulated in human liver carcinoma compared with normal liver. Its expression in colorectal cancers may contribute to the establishment of liver metastasis. In a different study, PRL-3 is found to be expressed in tumor metastasis and vasculature, regardless of the tumor source.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HPRL-3; Mutations: 6:OK; phosphatase of regenerating liver 3; potentially prenylated protein tyrosine phosphatase; PRL-3; PRL-R; protein tyrosine phosphatase 4a3; Protein tyrosine phosphatase type IVA 3; protein tyrosine phosphatase type IVA, member 3; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3
Gene Aliases: AV088979; pPtp4a3; PRL-3; PRL-R; PRL3; PTP4A3
UniProt ID: (Human) O75365, (Mouse) Q9D658
Entrez Gene ID: (Human) 11156, (Mouse) 19245, (Rat) 362930
regulation of transcription, DNA-templated
Notch signaling pathway
regulation of signal transduction
positive regulation of vascular permeability
endothelial cell migration
regulation of vascular endothelial growth factor signaling pathway
positive regulation of NIK/NF-kappaB signaling
positive regulation of establishment of protein localization
cellular response to leukemia inhibitory factor
protein dephosphorylation
dephosphorylation
peptidyl-tyrosine dephosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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