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Invitrogen

PRMT1 Polyclonal Antibody

查看其他16个PRMT1抗体

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PRMT1 Polyclonal Antibody

产品信息

PA1-30275

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:100
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 316-347 amino acids from the C-terminal region of human PRMT1.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2 mg/mL

规格

800 µg

纯化类型

Ammonium sulfate precipitation

保存液

PBS

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_1959925

产品详细信息

PA1-30275 detects PRMT1 from human samples.

靶标信息

PRMT1 is a member of the protein arginine N-methyltransferase (PRMT) family. Arginine methylation is an irreversible post translational modification which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These proteins include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology. Increased expression of PRMT1 may play a role in various types of cancer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2; highly conserved protein 1; Histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HRMT1L2; Interferon receptor 1-bound protein 4; Protein arginine N-methyltransferase 1; protein arginine N-methyltransferase 1 isoform 10; protein arginine N-methyltransferase 1 isoform 11; protein arginine N-methyltransferase 1 isoform 12; protein arginine N-methyltransferase 1 isoform 13; protein arginine N-methyltransferase 1 isoform 14; protein arginine N-methyltransferase 1 isoform 15; protein arginine N-methyltransferase 1 isoform 16; protein arginine N-methyltransferase 1 isoform 17; protein arginine N-methyltransferase 1 isoform 18; protein arginine N-methyltransferase 1 isoform 19; protein arginine N-methyltransferase 1 isoform 20; protein arginine N-methyltransferase 1 isoform 21; protein arginine N-methyltransferase 1 isoform 22; protein arginine N-methyltransferase 1 isoform 23; protein arginine N-methyltransferase 1 isoform 24; protein arginine N-methyltransferase 1 isoform 25; protein arginine N-methyltransferase 1 isoform 26; protein arginine N-methyltransferase 1 isoform 27; protein arginine N-methyltransferase 1 isoform 28; protein arginine N-methyltransferase 1 isoform 29; protein arginine N-methyltransferase 1 isoform 30; protein arginine N-methyltransferase 1 isoform 31; protein arginine N-methyltransferase 1 isoform 32; protein arginine N-methyltransferase 1 isoform 33; protein arginine N-methyltransferase 1 isoform 34; protein arginine N-methyltransferase 1 isoform 35; protein arginine N-methyltransferase 1 isoform 36; protein arginine N-methyltransferase 1 isoform 37; protein arginine N-methyltransferase 1 isoform 38; protein arginine N-methyltransferase 1 isoform 39; protein arginine N-methyltransferase 1 isoform 4; protein arginine N-methyltransferase 1 isoform 40; protein arginine N-methyltransferase 1 isoform 41; protein arginine N-methyltransferase 1 isoform 42; protein arginine N-methyltransferase 1 isoform 43; protein arginine N-methyltransferase 1 isoform 44; protein arginine N-methyltransferase 1 isoform 45; protein arginine N-methyltransferase 1 isoform 46; protein arginine N-methyltransferase 1 isoform 47; protein arginine N-methyltransferase 1 isoform 48; protein arginine N-methyltransferase 1 isoform 5; protein arginine N-methyltransferase 1 isoform 6; protein arginine N-methyltransferase 1 isoform 7; protein arginine N-methyltransferase 1 isoform 8; protein arginine N-methyltransferase 1 isoform 9; unnamed protein product

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基因别名: ANM1; HCP1; HMT2; HRMT1L2; IR1B4; PRMT1

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UniProt ID: (Human) Q99873

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Entrez Gene ID: (Human) 3276

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功能
RNA binding protein binding methyltransferase activity N-methyltransferase activity protein methyltransferase activity methyl-CpG binding protein-arginine N-methyltransferase activity transferase activity enzyme binding protein-arginine omega-N monomethyltransferase activity protein-arginine omega-N asymmetric methyltransferase activity histone methyltransferase activity identical protein binding histone methyltransferase activity (H4-R3 specific) mitogen-activated protein kinase p38 binding GATOR1 complex binding histone H4 methyltransferase activity S-adenosyl-L-methionine binding
参与通路
double-strand break repair via homologous recombination in utero embryonic development chromatin remodeling regulation of transcription, DNA-templated protein methylation cellular response to DNA damage stimulus cell surface receptor signaling pathway positive regulation of cell proliferation RNA splicing negative regulation of translation peptidyl-arginine methylation viral protein processing BMP signaling pathway regulation of BMP signaling pathway negative regulation of BMP signaling pathway neuron projection development cellular response to nutrient levels methylation cellular response to amino acid starvation TORC1 signaling positive regulation of erythrocyte differentiation regulation of megakaryocyte differentiation negative regulation of megakaryocyte differentiation positive regulation of translation negative regulation of translational initiation negative regulation of JNK cascade positive regulation of hemoglobin biosynthetic process cardiac muscle tissue development protein homooligomerization cellular response to methionine protein localization to lysosome membraneless organelle assembly positive regulation of p38MAPK cascade negative regulation of TORC1 signaling positive regulation of TORC1 signaling positive regulation of double-strand break repair via homologous recombination negative regulation of double-strand break repair via homologous recombination
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