Invitrogen

PRMT1 Polyclonal Antibody

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说明书
实验方案
问题与答案
技术支持
PRMT1 Polyclonal Antibody

产品信息

PA5-17302

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
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产品规格

种属反应

Human, Mouse, Non-human primate, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to the carboxy terminus of human PRMT1
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

24.1 µg/mL

纯化类型

Antigen affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

no preservative

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10979983

产品详细信息

It is not recommended to aliquot this antibody.

This antibody is not cross-reactive with other PRMT proteins.

靶标信息

PRMT1 is a member of the protein arginine N-methyltransferase (PRMT) family. Arginine methylation is an irreversible post translational modification which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These proteins include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology. Increased expression of PRMT1 may play a role in various types of cancer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: arginine N-methyltransferase 1; heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2; heterogeneous nuclear ribonucleoproteins methyltransferase-like 2; Histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; Interferon receptor 1-bound protein 4; Protein arginine N-methyltransferase 1

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基因别名: 6720434D09Rik; ANM1; AW214366; HCP1; HMT2; HRMT1L2; IR1B4; Mrmt1; PRMT1

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UniProt ID: (Human) Q2VP93, (Mouse) Q9JIF0, (Rat) Q63009

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Entrez Gene ID: (Human) 3276, (Mouse) 15469, (Rat) 60421

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功能
protein binding methyltransferase activity N-methyltransferase activity protein methyltransferase activity methyl-CpG binding protein-arginine N-methyltransferase activity enzyme binding protein-arginine omega-N asymmetric methyltransferase activity histone methyltransferase activity identical protein binding histone methyltransferase activity (H4-R3 specific) poly(A) RNA binding mitogen-activated protein kinase p38 binding rRNA (adenine-N6,N6-)-dimethyltransferase activity protein C-terminal carboxyl O-methyltransferase activity tRNA (guanine-N2-)-methyltransferase activity C-methyltransferase activity O-methyltransferase activity S-methyltransferase activity RNA methyltransferase activity mRNA methyltransferase activity tRNA methyltransferase activity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity histone-arginine N-methyltransferase activity rRNA methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity rRNA (adenine-N6-)-methyltransferase activity DNA-methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity rRNA (cytosine-C5-)-methyltransferase activity selenocysteine methyltransferase activity arginine N-methyltransferase activity [cytochrome c]-arginine N-methyltransferase activity lysine N-methyltransferase activity protein-lysine N-methyltransferase activity tRNA (uracil) methyltransferase activity tRNA (guanine) methyltransferase activity tRNA (adenine) methyltransferase activity tRNA (cytosine) methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity tRNA (adenine-N1-)-methyltransferase activity rRNA (adenine) methyltransferase activity rRNA (cytosine) methyltransferase activity rRNA (guanine) methyltransferase activity rRNA (uridine) methyltransferase activity transferase activity protein C-terminal leucine carboxyl O-methyltransferase activity 1-phenanthrol methyltransferase activity protein-arginine N5-methyltransferase activity snoRNP binding methylarsonite methyltransferase activity dimethylarsinite methyltransferase activity 4,5-dihydroxybenzo(a)pyrene methyltransferase activity 1-hydroxypyrene methyltransferase activity 1-hydroxy-6-methoxypyrene methyltransferase activity protein-arginine omega-N monomethyltransferase activity demethylmenaquinone methyltransferase activity cobalt-precorrin-6B C5-methyltransferase activity cobalt-precorrin-7 C15-methyltransferase activity cobalt-precorrin-5B C1-methyltransferase activity cobalt-precorrin-3 C17-methyltransferase activity dimethylamine methyltransferase activity hydroxyneurosporene-O-methyltransferase activity tRNA (adenine-57, 58-N(1)-) methyltransferase activity methylamine-specific methylcobalamin:coenzyme M methyltransferase activity trimethylamine methyltransferase activity methanol-specific methylcobalamin:coenzyme M methyltransferase activity monomethylamine methyltransferase activity P-methyltransferase activity Se-methyltransferase activity 2-phytyl-1,4-naphthoquinone methyltransferase activity tRNA (uracil-2'-O-)-methyltransferase activity tRNA (cytosine-2'-O-)-methyltransferase activity phosphomethylethanolamine N-methyltransferase activity tRNA (cytosine-3-)-methyltransferase activity rRNA (cytosine-2'-O-)-methyltransferase activity rRNA (cytosine-N4-)-methyltransferase activity trihydroxyferuloyl spermidine O-methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity protein modifying enzyme
参与通路
regulation of transcription, DNA-templated protein methylation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest cell surface receptor signaling pathway histone methylation peptidyl-arginine methylation peptidyl-arginine methylation, to asymmetrical-dimethyl arginine neuron projection development histone H4-R3 methylation positive regulation of erythrocyte differentiation negative regulation of megakaryocyte differentiation positive regulation of hemoglobin biosynthetic process positive regulation of p38MAPK cascade in utero embryonic development methylation peptidyl-arginine N-methylation peptidyl-arginine omega-N-methylation liver regeneration
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