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Invitrogen
PRMT1 Polyclonal Antibody
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PRMT1 Antibody (PA5-81570) in ICC/IF
Immunofluorescence staining of PRMT1 in HeLa cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with PRMT1 Polyclonal Antibody (Product # PA5-81570, 1:1,000) at 4°C overnight. Then cells were stained with the Alexa Fluor®594-conjugated Goat Anti-rabbit IgG secondary antibody (red). Positive staining was localized to nucleus..
产品信息
PA5-81570
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to the C-terminus of the Human PRMT1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human PRMT1.
靶标信息
PRMT1 is a member of the protein arginine N-methyltransferase (PRMT) family. Arginine methylation is an irreversible post translational modification which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These proteins include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology. Increased expression of PRMT1 may play a role in various types of cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2; Histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; Interferon receptor 1-bound protein 4; Protein arginine N-methyltransferase 1
基因别名: ANM1; HCP1; HMT2; HRMT1L2; IR1B4; PRMT1
UniProt ID: (Human) Q2VP93
Entrez Gene ID: (Human) 3276
protein binding
methyltransferase activity
N-methyltransferase activity
protein methyltransferase activity
methyl-CpG binding
protein-arginine N-methyltransferase activity
enzyme binding
protein-arginine omega-N asymmetric methyltransferase activity
histone methyltransferase activity
identical protein binding
histone methyltransferase activity (H4-R3 specific)
poly(A) RNA binding
mitogen-activated protein kinase p38 binding
protein modifying enzyme
regulation of transcription, DNA-templated
protein methylation
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cell surface receptor signaling pathway
histone methylation
peptidyl-arginine methylation
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
neuron projection development
histone H4-R3 methylation
positive regulation of erythrocyte differentiation
negative regulation of megakaryocyte differentiation
positive regulation of hemoglobin biosynthetic process
positive regulation of p38MAPK cascade
