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Invitrogen
PROK2 Polyclonal Antibody
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PROK2 Antibody (PA5-110221) in IHC (P)
Immunohistochemistry analysis of PROK2 in paraffin-embedded mouse brain. Samples were incubated with PROK2 Polyclonal antibody (Product # PA5-110221) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-110221
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 20-129 of human PROK2 (NP_001119600.1).
偶联物
形式
Liquid
浓度
0.87 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LTPRAGDAAV ITGACDKDSQ CGGGMCCAVS IWVKSIRICT PMGKLGDSCH PLTRKNNFGN GRQERRKRKR SKRKKEVPFF GRRMHHTCPC LPGLACLRTS FNRFICLAQK
靶标信息
Prokineticin-2 (PK2) is a cysteine-rich secreted protein that is expressed in the suprachiasmatic nucleus (SCN) with receptors located in the critical autonomic control centers of the brain. It has a depolarizing effect on neurons expressing the receptor. PK2 is predominantly controlled by the endogenous circadian clock, but light also plays a modulatory role. PK2 functions as a critical SCN output molecule responsible for circadian locomotor rhythms. PK2 expression is high during the day, and responsive to nocturnal light pulses. PK2 also functions as a chemoattractant for subventricular zone-derived neuronal progenitors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bombina variegata 8 kD protein; Bombina variegata 8kDa protein; Bv 8 homolog (Bombina variegata); homolog of mouse Bv8 (Bombina variegata 8 kDa); homolog of mouse Bv8 (Bombina variegata 8 kDa); prokineticin 2; PK2; prokineticin 1; prokineticin 2 beta; Prokineticin-2; Protein Bv8 homolog
基因别名: BV8; HH4; KAL4; MIT1; PK2; Prok1; PROK2
UniProt ID: (Human) Q9HC23, (Rat) Q8R413, (Mouse) Q9QXU7
Entrez Gene ID: (Human) 60675, (Rat) 192206, (Mouse) 50501
activation of MAPK activity
angiogenesis
chemotaxis
inflammatory response
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
spermatogenesis
circadian rhythm
cell proliferation
positive regulation of cell proliferation
sensory perception of pain
negative regulation of apoptotic process
regulation of angiogenesis
positive regulation of smooth muscle contraction
rhythmic process
epicardium-derived cardiac endothelial cell differentiation
coronary vasculature development
vasculogenesis involved in coronary vascular morphogenesis
epicardium-derived cardiac vascular smooth muscle cell differentiation
