Invitrogen

PRRX1 Polyclonal Antibody

Name: PRRX1 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-38008
Price: 5163.00 CNY
Availability: InStock

查看其他13个PRRX1抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (1)

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PRRX1 Antibody (PA5-38008) in WB

Western Blot analysis of PRRX1 in HeLa cell lysate with PRRX1 Polyclonal Antibody (Product # PA5-38008) at 1 µg/mL.

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

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产品信息

PA5-38008

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-2 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

19 amino acid peptide near the center of human PRRX1

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

100 µg

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Ambient (domestic); Wet ice (international)

AB_2554612

产品详细信息

A recommended positive control is HeLa cell lysate.

At least two isoforms of PRRX1 are known to exist; this antibody will detect both isoforms.

靶标信息

The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. PRX1 (paired related homeobox 1), also known as PRRX1, PMX1 or PHOX1, is a 245 amino acid protein that contains one OAR domain and one homeobox DNA-binding domain and belongs to the paired homeobox family. Localized to the nucleus, PRX1 functions as a transcriptional co-activator that enhances the DNA-binding activity of serum response factor (SRF), thereby mediating the induction of SRF-dependent gene expression by growth and differentiation factors. Additionally, PRX1 regulates the transcriptional activities of creatine kinase-M (muscle), thereby playing a role in the establishment of mesodermal muscle types. PRX1 exists as two alternatively spliced isoforms, designated PMX1-A and PMX1-B.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: homeobox protein K-2; homeobox protein mHox; homeobox protein PHOX1; muscle homeobox protein; negative bone gene regulator/Pmx-Prx-MHox homolog; paired mesoderm homeobox 1; paired-related homeobox protein 1; rHox; unnamed protein product

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基因别名: A230024N07Rik; AGOTC; K-2; mHox; MHox1; PHOX1; Pmx; PMX1; PRX-1; PRX1

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UniProt ID: (Human) P54821, (Rat) P63014, (Mouse) P63013

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Entrez Gene ID: (Human) 5396, (Rat) 266813, (Mouse) 18933

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功能

RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding protein binding obsolete general RNA polymerase II transcription factor activity RNA polymerase II sequence-specific DNA binding transcription factor binding HMG box domain binding

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